Synthesis, anticancer and larvicidal activities of a novel Schiff base ligand, 3-((2-((1-(4-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-(p-tolyl)butanamide and its Mn(II), Fe(III), Co(II), Ni(II) and Zn(II) complexes

• Published in: Results in Chemistry 2021-01, Vol.3, p.100166, Article 100166
• Main Authors: Subin Kumar, K., Reena, V.N., Aravindakshan, K.K.
• Format: Article
• Language: English
• Subjects: Anticancer and Larvicidal activity; Cytotoxicity; Metal complexes; Schiff base ligand
• ISSN: 2211-7156; 2211-7156
• DOI: 10.1016/j.rechem.2021.100166

•Synthesized a new Schiff base ligand and its Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes.•Ligand and complexes showed better cytotoxic activity.•Zn(II) complex performed in vivo anticancer activity showed its potential activity against ascites and solid tumors.•Ligand and metal complexes showed better larvicidal activity. A novel Schiff base ligand, 3-((2-((1-(4-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-(p-tolyl)butanamide (H2L) and its some metal, Mn(II), Fe(III), Co(II), Ni(II) and Zn(II) complexes have been synthesized. Schiff base ligand was characterized by analytically and HRMS, IR-, 1H NMR, 13C NMR- and UV–Vis spectral techniques. In addition to this molar conductance and magnetic moment calculations were used to characterize metal complexes. The ligand and its complexes have been evaluated for their in vitro cytotoxicity against Dalton’s Lymphoma Ascites (DLA) cell lines by Trypan Blue Exclusion method. Zn(II) complex was selected to evaluate its efficiency against EAC (Earlich Ascites Carcinoma) induced ascites tumor and DLA induced solid tumor in Swiss Albino female mice. The results are expressed with an IC50 value, 48 µg/ml, which indicated that Zn(II) complex showed as a potential anticancer agent. Metal complexes of Mn(II), Fe(III), Co(II), Ni(II) and Zn(II) are taken to examine for their larvicidal activity against larvae of Cx. quinquefasciatus. The statistically analyzed results showed that the sample of Zn(II) complex exhibited potential larvicidal activity.