The role of vascular mimicry as a biomarker in malignant melanoma: a systematic review and meta-analysis

Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). We performed a systematic literature review to evaluate the diagnostic and prognostic accur...

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Bibliographic Details
Published in:BMC cancer 2019-11, Vol.19 (1), p.1134-1134, Article 1134
Main Authors: Zhang, Zhenhua, Imani, Saber, Shasaltaneh, Marzieh Dehghan, Hosseinifard, Hossein, Zou, Linglin, Fan, Yu, Wen, Qinglian
Format: Article
Language:English
Subjects:
Accuracy
Analysis
Bias
Biomarkers
Boolean
Cancer therapies
Diagnosis
Endothelial cells
Endothelium
Female
Health aspects
Humans
Literature reviews
Male
Malignant melanoma
Medical prognosis
Medical research
Melanoma
Melanoma - blood supply
Melanoma - diagnosis
Melanoma - pathology
Meta-analysis
Metastasis
Microvasculature
Mimicry
Mortality
Neovascularization, Pathologic - diagnosis
Neovascularization, Pathologic - pathology
Observational Studies as Topic
Odds Ratio
Population
Prognosis
Researchers
ROC Curve
Sensitivity and Specificity
Skin cancer
Studies
Systematic review
Therapeutic applications
Tumors
Vasculogenic mimicry
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Summary:Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). We performed a systematic literature review to evaluate the diagnostic and prognostic accuracy of VM status for overall survival of MM patients. The quality of the included studies was evaluated using the QUADAS-2 tool. Diagnostic capacity of VM variables, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under summary receiver operating characteristic (SROC), were pooled using Meta-DiSc software. A retrospective observational study was conducted based on twelve clinical studies including 978 clinically confirmed melanoma patients with proportion (P). VM+ melanoma cells were associated with poor prognosis in 38% of MM group (P = 0.35, 95% confidence intervals (CI): 0.27-0.42, p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-019-6350-5