Pediatric Behçet's disease - clinical aspects and current concepts

Behçet's Disease was first described by a Turkish dermatologist, Hulusi Behçet, in 1937 as a triple symptom complex; aphthous stomatitis, genital ulcers, and uveitis. Today, in light of current trials and experiments, we know that the disease may have a wider involvement with a multisystemic re...

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Bibliographic Details
Published in:European journal of rheumatology 2020-02, Vol.7 (Suppl1), p.S38-47
Main Authors: Yıldız, Mehmet, Köker, Oya, Adrovic, Amra, Şahin, Sezgin, Barut, Kenan, Kasapçopur, Özgür
Format: Article
Language:English
Subjects:
Canker sores
Childhood
Children
Diseases
Epidemiology
Health aspects
Invited Review
Morbidity
Mortality
Pediatric diseases
Pediatrics
Stomatitis
Ulcers
Uveitis
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Summary:Behçet's Disease was first described by a Turkish dermatologist, Hulusi Behçet, in 1937 as a triple symptom complex; aphthous stomatitis, genital ulcers, and uveitis. Today, in light of current trials and experiments, we know that the disease may have a wider involvement with a multisystemic recurrent course, causing significant morbidity and mortality. However, there are still unanswered questions, particularly about Pediatric Behçet's Disease. Although several immunological and genetic associations have been demonstrated, the real etiologic mechanism of the disease is unclear. The diagnosis is difficult due to its rarity in childhood, the lack of validation of the diagnostic criteria obtained from adult studies, and the inadequacy of large case-controlled studies. Also, the management is challenging and controversial due to the various geographic distribution of clinical spectrum. New therapeutic options under development in light of pathogenetic hypothesis seem to be promising.
ISSN:2147-9720
2148-4279
DOI:10.5152/eurjrheum.2019.19121