Serial mediating effects of childhood trauma and conduct behaviors on the impact of family history among patients with alcohol use disorder

Family history (FH) of alcoholism increases the risk of alcohol use disorder (AUD); however, the contribution of childhood trauma (CT) in this respect remains unclear. This study investigated the relationship between FH and AUD-related clinical characteristics (social onset, antisocial tendency, and...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.7196-7196, Article 7196
Main Authors: Han, Min Jeong, Kim, Shin Tae, Park, Chun Il, Hwang, Syung Shick, Kim, Hae Won, Kang, Jee In, Kim, Se Joo
Format: Article
Language:English
Subjects:
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Adverse childhood experiences
Alcohol use
Alcoholic beverages
Alcohols
Childhood
Children
Drinking behavior
Genetics
Humanities and Social Sciences
multidisciplinary
Patients
Science
Science (multidisciplinary)
Social behavior
Trauma
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Summary:Family history (FH) of alcoholism increases the risk of alcohol use disorder (AUD); however, the contribution of childhood trauma (CT) in this respect remains unclear. This study investigated the relationship between FH and AUD-related clinical characteristics (social onset, antisocial tendency, and severity of problematic alcohol consumption) through the mediating effects of childhood trauma (CT) and conduct behaviors (CB) in a Korean male population with AUD. A total of 304 patients hospitalized for AUD at 16 psychiatric hospitals completed standardized questionnaires, including self-rated scales. Mediation analyses were performed using the SPSS macro PROCESS. Individuals with positive FH (133, 44%) had greater CT and CB and more severe AUD-related clinical characteristics than those without FH (171, 56%). In the present serial mediation model, FH had significant direct and indirect effects on AUD-related clinical characteristics through CT and CB. Indirect effects were 21.3% for social onset, 46.3%, antisocial tendency, and 37.9% for problematic drinking. FH directly contributed to AUD-related clinical characteristics, and CT and CB played mediating roles. This highlights the importance of careful intervention and surveillance of adverse childhood experiences and conduct disorder to prevent and mitigate alcohol-related problems in individuals with FH of AUD.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-57861-x