Inflammation-based assessment for the risk stratification of mortality in patients with heart failure

The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association between th...

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Bibliographic Details
Published in:Scientific reports 2021-07, Vol.11 (1), p.14989-14989, Article 14989
Main Authors: Itagaki, Tadashi, Motoki, Hirohiko, Otagiri, Kyuhachi, Machida, Keisuke, Takeuchi, Takahiro, Kanai, Masafumi, Kimura, Kazuhiro, Higuchi, Satoko, Minamisawa, Masatoshi, Kitabayashi, Hiroshi, Kuwahara, Koichiro
Format: Article
Language:English
Subjects:
692/4019
692/53/2422
Blood pressure
Brain natriuretic peptide
Congestive heart failure
Heart failure
Hemoglobin
Humanities and Social Sciences
Inflammation
Malnutrition
Mortality
multidisciplinary
Multivariate analysis
Prognosis
Renal function
Science
Science (multidisciplinary)
Ventricle
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Summary:The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association between the GPS and mortality in patients with HF, we assessed 870 patients who were 20 years old and more and had been admitted for acute decompensated HF. The GPS ranged from 0 to 2 points as previously reported. Over the 18-month follow-up (follow-up rate, 83.9%), 143 patients died. Increasing GPS was associated with higher HF severity assessed by New York Heart Association functional class and B-type natriuretic peptide (BNP) levels. Kaplan–Meier analysis showed significant associations for mortality and increased GPS. In multivariate analysis, compared to the GPS 0 group, the GPS 2 group was associated with high mortality (hazard ratio 2.92, 95% confidence interval 1.77–4.81, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-94525-6