Association between weight-adjusted-waist index and the risk of hyperuricemia in adults: a population-based investigation

ObjectiveThis investigation sought to elucidate the potential correlation between a recently characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and hyperuricemia.MethodsA cross-sectional design was employed in this study, featuring both hyperuricemic and non-hyperuricemic s...

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Published in:Frontiers in endocrinology (Lausanne) 2023-10, Vol.14, p.1236401-1236401
Main Authors: Ding, Yunyi, Xu, Zhuohan, Zhou, Xue, Luo, Yichen, Xie, Ruijie, Li, Yayu
Format: Article
Language:English
Subjects:
cross-sectional study
Endocrinology
hyperuricemia
NHANES
obesity
weight-adjusted-waist index
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Summary:ObjectiveThis investigation sought to elucidate the potential correlation between a recently characterized adiposity metric, termed the Weight-Adjusted-Waist Index (WWI) and hyperuricemia.MethodsA cross-sectional design was employed in this study, featuring both hyperuricemic and non-hyperuricemic subjects with complete WWI data, sourced from the National Health and Nutrition Examination Survey (NHANES) spanning 2017 to March 2020. WWI was calculated utilizing the formula which involves the division of waist circumference (WC) by the square root of the body weight. In order to determine the relationship between WWI and hyperuricemia, both univariate and multivariate logistic regression models, appropriately weighted, were employed in the analysis. The linearity of relationships was validated using smooth curve fitting. Additionally, subgroup evaluations and interaction assessments were conducted.ResultsThe study sample comprised 7437 subjects, yielding a hyperuricemia prevalence of 18.22%. Stratifying WWI into tertiles, a progressive rise in hyperuricemia prevalence was evident with increasing WWI (Tertile 1: 11.62%, Tertile 2: 17.91%, Tertile 3: 25.13%). The odds ratio (OR) demonstrated that individuals within the highest WWI tertile were significantly more prone to hyperuricemia than those in the lowest tertile (OR = 2.41, 95% CI: 1.88-3.08).ConclusionThis study provides evidence that an elevated WWI is correlated with an increased risk of hyperuricemia in the adult population of the United States. These results suggest that WWI may serve as a viable anthropometric indicator for predicting hyperuricemia.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1236401