Sinobronchial Syndrome Patients with Suspected Non-Tuberculous Mycobacterium Infection Exacerbated by Exophiala dermatitidis Infection

is an environmental black fungus that rarely causes respiratory infections, yet its pathophysiological features and treatment regimens have not been established. Two cases of exacerbations of chronic bronchitis and sinusitis due to infection in Japan are presented. Both patients were women, and non-...

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Bibliographic Details
Published in:Infection and drug resistance 2022-03, Vol.15, p.1135-1141
Main Authors: Watanabe, Yuji, Sano, Hirohito, Konno, Shuichi, Kamioka, Yasuhiro, Hariu, Maya, Takano, Kazuki, Yamada, Mitsuhiro, Seki, Masafumi
Format: Article
Language:English
Subjects:
Amphotericin B
Antibodies
Antifungal agents
Antigens
Antiparasitic agents
black fungus
bronchiectasis
Bronchitis
bronchoscope
Care and treatment
Case Series
Caspofungin
Chronic infection
Clarithromycin
Cystic fibrosis
Diabetes
Diagnosis
Ethambutol
Exophiala
Fungi
Health aspects
Immunocompetence
Infections
Itraconazole
Laboratories
Mass spectrometry
Mycobacterium
Pathogens
Patients
rheumatoid arthritis
Rheumatoid factor
Rifampin
Scientific imaging
Sinusitis
Tomography
Tuberculosis
Viscosity
Voriconazole
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Description
Summary:is an environmental black fungus that rarely causes respiratory infections, yet its pathophysiological features and treatment regimens have not been established. Two cases of exacerbations of chronic bronchitis and sinusitis due to infection in Japan are presented. Both patients were women, and non-tuberculous (NTM) infection was suspected based on chest radiological findings, but was detected from bronchial lavage fluid and nasal mucus, respectively. Both cases were successfully treated by antifungal agents such as liposomal amphotericin B, voriconazole, and itraconazole, but clarithromycin, rifampicin, ethambutol, and sitafloxacin for NTM were not effective. can become a respiratory pathogen, especially in patients with chronic sinobronchial syndrome.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S359646