Haloarchaeal carotenoids exert an in vitro antiproliferative effect on human breast cancer cell lines

• Published in: Scientific reports 2023-05, Vol.13 (1), p.7148-7148, Article 7148
• Main Authors: Giani, Micaela, Montoyo-Pujol, Yoel Genaro, Peiró, Gloria, Martínez-Espinosa, Rosa María
• Format: Article
• Language: English
• Subjects: 631/1647/2196/2197; 631/67/1347; Aggressive behavior; Antineoplastic Agents - pharmacology; Apoptosis; Breast cancer; Breast Neoplasms - drug therapy; Carotenoids; Carotenoids - pharmacology; Carotenoids - therapeutic use; Cell Line, Tumor; Cell Proliferation; Cell size; Cytotoxicity; Epithelium; Female; Humanities and Social Sciences; Humans; multidisciplinary; Oxidative stress; Phenotypes; Science; Science (multidisciplinary); Triple Negative Breast Neoplasms - genetics; Tumor cell lines
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-34419-x

Oxidative stress has been linked to the onset and progression of different neoplasia. Antioxidants might help prevent it by modulating biochemical processes involved in cell proliferation. Here, the aim was to evaluate the in vitro cytotoxic effect of Haloferax mediterranei bacterioruberin-rich carotenoid extracts (BRCE) (0–100 µg/ml) in six BC cell lines, representative of the intrinsic phenotypes and a healthy mammary epithelium cell line. Cell index values were obtained using xCELLigence RTCA System. Furthermore, cell diameter, viability, and concentration were measured at 12 h, 24 h, and 30 h. We found that BC cells were selectively affected by BRCE (SI > 1, p