Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF

The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antio...

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Published in:iScience 2020-06, Vol.23 (6), p.101156-101156, Article 101156
Main Authors: Osorio-Toribio, Génesis, Velásquez-Hernández, Miriam de J., Mileo, Paulo G.M., Zárate, J. Antonio, Aguila-Rosas, Javier, Leyva-Gómez, Gerardo, Sánchez-Sánchez, Roberto, Magaña, Jonathan J., Pérez-Díaz, Mario Alberto, Lázaro, Isabel Abánades, Forgan, Ross S., Maurin, Guillaume, Lima, Enrique, Ibarra, Ilich A.
Format: Article
Language:English
Subjects:
Chemical Sciences
Chemistry
Inorganic Chemistry
Materials Structure
Medicine
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Summary:The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs). [Display omitted] •MFM-300(Sc) presents good stability and biocompatibility•FER@MFM-300(Sc) allows the long-term transdermal release of ferulate (FER–)•FER@MFM-300(Sc) prevents the photodegradation of FER Medicine; Chemistry; Inorganic Chemistry; Materials Structure
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2020.101156