Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome

To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and h...

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Published in:Jornal brasileiro de pneumologia 2019, Vol.45 (3), p.e20170164-e20170164
Main Authors: Bosco, Adriane Dal, Schedler, Filipe Boeira, Colares, Josieli Raskopf, Schemitt, Elisângela Gonçalves, Hartmann, Renata Minuzzo, Forgiarini Junior, Luiz Alberto, Dias, Alexandre Simões, Marroni, Norma Possa
Format: Article
Language:English
Subjects:
Ducto biliar
Melatonina
Original
Pulmão
RESPIRATORY SYSTEM
Síndrome Hepatopulmonar
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Summary:To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung / body weight ratio (%) were evaluated. When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups. The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.
ISSN:1806-3713
1806-3756
1806-3756
DOI:10.1590/1806-3713/e20170164