Exogenous capture accounts for fundamental differences between pro- and antisaccade performance

• Published in: eLife 2022-07, Vol.11
• Main Authors: Goldstein, Allison T, Stanford, Terrence R, Salinas, Emilio
• Format: Article
• Language: English
• Subjects: Accuracy; decision making; Eye Movements; Humans; Nerves; Neuroscience; Photic Stimulation; Physiological aspects; Psychomotor Performance - physiology; Reaction Time - physiology; Research Advance; Saccades; Saccades (Eye movements); Saccadic eye movements; salience; visual attention; Visual pathways; Visual stimuli; visuomotor control
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.76964

To generate the next eye movement, oculomotor circuits take into consideration the physical salience of objects in view and current behavioral goals, exogenous and endogenous influences, respectively. However, the interactions between exogenous and endogenous mechanisms and their dynamic contributions to target selection have been difficult to resolve because they evolve extremely rapidly. In a recent study (Salinas et al., 2019), we achieved the necessary temporal precision using an urgent variant of the antisaccade task wherein motor plans are initiated early and choice accuracy depends sharply on when exactly the visual cue information becomes available. Empirical and modeling results indicated that the exogenous signal arrives ∼80 ms after cue onset and rapidly accelerates the (incorrect) plan toward the cue, whereas the informed endogenous signal arrives ∼25 ms later to favor the (correct) plan away from the cue. Here, we scrutinize a key mechanistic hypothesis about this dynamic, that the exogenous and endogenous signals act at different times and independently of each other. We test quantitative model predictions by comparing the performance of human participants instructed to look toward a visual cue or away from it under high urgency. We find that, indeed, the exogenous response is largely impervious to task instructions; it simply flips its sign relative to the correct choice, and this largely explains the drastic differences in psychometric performance between the two tasks. Thus, saccadic choices are strongly dictated by the alignment between salience and behavioral goals.