Lymphocutaneous nocardiosis caused by in an immunocompetent patient: a case report

• Published in: Journal of international medical research 2020-01, Vol.48
• Main Authors: Siying Li, Xiangfei Xu, Min Wu, Jing Zhu, Panpan Cen, Jiexia Ding, Shenghai Wu, Jie Jin
• Format: Article
• Language: English
• ISSN: 1473-2300
• DOI: 10.1177/0300060519897690

Nocardia usually manifests as opportunistic infections in immunocompromised hosts. Here, we report a rare case of an immunocompetent patient with lymphocutaneous nocardiosis. The patient was a 34-year-old man presenting with fever, multiple scattered pustules on both upper limbs and several subcutaneous nodules on the left elbow and forearm. Skin biopsy of the subcutaneous nodule revealed suppurative inflammation of the lymph nodes. Pus cultures were finally identified as Nocardia brasiliensis . The patient fully recovered without relapse after receiving optimized antimicrobial therapy consisting of linezolid combined with sulfonamides. Nocardiosis is a rare opportunistic disease which may be fatal and usually affects immunocompromised hosts, resulting in suppurative and granulomatous inflammation. Nocardia has a long culture cycle, is difficult to diagnose, and is more likely to be neglected in healthy young people. The present case suggests that physicians should be aware that nocardiosis is a differential diagnosis to consider in patients with suppurative infection, especially when anti-infective treatment is ineffective.