Intrastriatal gradient analyses of 18F-FDOPA PET scans for differentiation of Parkinsonian disorders

• Published in: NeuroImage clinical 2020-01, Vol.25, p.102161, Article 102161
• Main Authors: Stormezand, Gilles N., Chaves, Lumi T., Vállez García, David, Doorduin, Janine, De Jong, Bauke M., Leenders, Klaus L., Kremer, Berry P.H., Dierckx, Rudi A.J.O.
• Format: Article
• Language: English
• Subjects: Aged; Atypical Parkinsonism; Caudate Nucleus - diagnostic imaging; Corpus Striatum - diagnostic imaging; Diagnosis, Differential; Dihydroxyphenylalanine - analogs & derivatives; Dihydroxyphenylalanine - pharmacokinetics; Female; Humans; Male; Middle Aged; Neuroimaging - methods; Parkinson Disease - diagnostic imaging; Parkinson's disease; Parkinsonian Disorders - diagnostic imaging; PET; Positron-Emission Tomography - methods; Putamen - diagnostic imaging; Regular; Retrospective Studies
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2019.102161

•FDOPA PET allows quantification of presynaptic dopaminergic functioning in vivo.•Subregional analysis within the striatum provides additional diagnostic value for differentiation within Parkinsonian disorders.•Depletion of F-DOPA uptake in both patients with idiopathic Parkinson's disease and patients with atypical Parkinsonism preferentially affects the posterior part of the putamen.•A more linear decrease of FDOPA uptake from the head of the caudate nucleus to the posterior putamen is present in patients with IPD than in APD. L -3,4-dihydroxy-6–18F-fluorophenylalanine (18F-DOPA PET may be used to distinguish subjects with Parkinsonism from those with symptoms not originating from impaired dopaminergic transmission. However, it is not routinely utilized to discriminate Idiopathic Parkinson's disease (IPD) from Atypical Parkinsonian Disorders (APD). We investigated the potential of FDOPA PET to discriminate between IPD and APD, with a focus on the anterior-to-posterior decline in het striatum, considered to be more specific for IPD. 18F-DOPA PET data from a total of 58 subjects were retrospectively analyzed. 28 subjects had idiopathic Parkinson's disease (14 male, 14 female; age at scan 61 +- 11,5), 13 atypical Parkinsonian disease (7 male, 6 females; age at scan: 69,6 +- 6,4) and 17 were controls (6 male, 11 female; age at scan 65,3 +-8,6). Regional striatal-to-occipital ratio's (RSOR's) were calculated, as well as multiple in-line VOI's from the caudate nucleus to the posterior part of the putamen. The linearity of anteroposterior decline was determined by a linear regression fit and associated R squared values. ROC curves were calculated to assess the diagnostic performance of these measurements. Data contralateral to the clinically most affected side were used for analysis. ROC curve analysis for differentiation between controls and Parkinsonism patients showed the highest AUC for the caudate nucleus-to-posterior putamen ratio (AUC = 0.930; p