Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population

Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomatous polyps (CAP) in the Chinese population. One thousand three hundred seventy five work...

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Bibliographic Details
Published in:BMC gastroenterology 2019-01, Vol.19 (1), p.14-14, Article 14
Main Authors: ChangxiChen, Mao, Yushan, Du, Juan, Xu, Yimin, Zhu, Zhongwei, Cao, Hongbao
Format: Article
Language:English
Subjects:
Adenomatous Polyps - epidemiology
Adenomatous Polyps - pathology
Adult
Aged
Antiulcer agents
Biopsy
Carbon
Carbon 13
Carcinoma
Care and treatment
Chemical industry
China
China - epidemiology
Colonoscopy
Colorectal adenomatous polyps
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - pathology
Comorbidity
Female
Gastric cancer
Gastritis
Gastroenterology
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - microbiology
Genotype & phenotype
Health risk assessment
Helicobacter infections
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Infection
Infections
Logistic Models
Logistic regression
Male
Malignancy
Medical research
Middle Aged
Mortality
Peptic ulcer
Polyps
Population
Prevalence
Regression analysis
Risk Factors
Tumors
Ulcers
Urea
Workers
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Description
Summary:Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomatous polyps (CAP) in the Chinese population. One thousand three hundred seventy five workers of China Petroleum and Chemical Corporation Sinopec Zhenhai Refining & Chemical Branch were recruited. Carbon-13 urea breathes test, and colorectal biopsies were utilized to detect H. pylori and CAP. The correlation between the number and distribution of CAP with H. pylori infection (HPI) was determined. Logistic regression models were applied to calculate the effect of H. pylori on the risk of CAP and pathway studio was used to attribute the cellular processes linking HPI and adenomatous polyps. One hundred Eighty participants were diagnosed as CAP, and 1195 participants were classified as healthy control. The prevalence of HPI in the CAP group was significantly higher than that in the healthy control group (57.8% verse 40.1%) (p
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-018-0918-4