Nonmercaptalbumin as an oxidative stress marker in Parkinson’s and PARK2 disease

• Published in: Annals of clinical and translational neurology 2020-03, Vol.7 (3), p.307-317
• Main Authors: Ueno, Shin‐Ichi, Hatano, Taku, Okuzumi, Ayami, Saiki, Shinji, Oji, Yutaka, Mori, Akio, Koinuma, Takahiro, Fujimaki, Motoki, Takeshige‐Amano, Haruka, Kondo, Akihide, Yoshikawa, Naoyuki, Nojiri, Takahiro, Kurano, Makoto, Yasukawa, Keiko, Yatomi, Yutaka, Ikeda, Hitoshi, Hattori, Nobutaka
• Format: Article
• Language: English
• Subjects: Age; Aged; Atrophy; Biomarkers; Biomarkers - blood; Chromatography, High Pressure Liquid; Female; Humans; Investigations; Male; Middle Aged; Movement disorders; Multiple System Atrophy - blood; Mutation; Oxidative stress; Oxidative Stress - physiology; Parkinson Disease - blood; Parkinson Disease - diagnosis; Parkinson Disease - genetics; Parkinson Disease - physiopathology; Parkinson's disease; Polyvinyl alcohol; Prospective Studies; Regression analysis; Serum Albumin - metabolism; Serum Albumin, Human - metabolism; Severity of Illness Index; Software; Statistical analysis; Supranuclear Palsy, Progressive - blood; Ubiquitin-Protein Ligases - genetics
• ISSN: 2328-9503; 2328-9503
• DOI: 10.1002/acn3.50990

Objective To investigate the oxidized albumin ratio, which is the redox ratio of human nonmercaptalbumin (HNA) to serum albumin (%HNA), as a biomarker in idiopathic Parkinson’s disease (iPD) and related neurodegenerative disorders. Methods This prospective study enrolled 216 iPD patients, 15 patients with autosomal recessive familial PD due to parkin mutations (PARK2), 30 multiple system atrophy (MSA) patients, 32 progressive nuclear palsy (PSP) patients, and 143 healthy controls. HNA was analyzed using modified high‐performance liquid chromatography and was evaluated alongside other parameters. Results iPD and PARK2 patients had a higher %HNA than controls (iPD vs. controls: odds ratio (OR) 1.325, P