Vitamin D and neurocognitive function

In recent years, emerging evidence has linked vitamin D not only to its known effects on calcium and bone metabolism, but also to many chronic illnesses involving neurocognitive decline. The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an...

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Bibliographic Details
Published in:Clinical interventions in aging 2014-01, Vol.9, p.559-568
Main Authors: Schlögl, Mathias, Holick, Michael F
Format: Article
Language:English
Subjects:
25(OH)D level
Age
Aged
Aging
Aging - physiology
Alzheimer Disease - etiology
Alzheimer's disease
Brain research
Cognition
Cognition & reasoning
Cognition - physiology
Cognition disorders
Cognitive Dysfunction - etiology
Complications and side effects
Cyclin-dependent kinases
Cytochrome
Dementia
Deoxyribonucleic acid
DNA
Fibroblasts
Fractures
Growth factors
Health aspects
Humans
Lymphoma
Malnutrition
Malnutrition - complications
Metabolism
Metabolites
Mild-cognitive impairment
Mortality
Neurology
Neuropathology
Older people
Pathology
Prostate
Proteins
Review
Risk factors
Systematic review
vascular dementia
Vitamin D
Vitamin D - metabolism
Vitamin D - physiology
Vitamin D deficiency
Vitamin D Deficiency - complications
Vitamin deficiency
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Description
Summary:In recent years, emerging evidence has linked vitamin D not only to its known effects on calcium and bone metabolism, but also to many chronic illnesses involving neurocognitive decline. The importance of vitamin D3 in reducing the risk of these diseases continues to increase due to the fact that an increasing portion of the population in developed countries has a significant vitamin D deficiency. The older population is at an especially high risk for vitamin D deficiency due to the decreased cutaneous synthesis and dietary intake of vitamin D. Recent studies have confirmed an association between cognitive impairment, dementia, and vitamin D deficiency. There is a need for well-designed randomized trials to assess the benefits of vitamin D and lifestyle interventions in persons with mild cognitive impairment and dementia.
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S51785