The Use of Tractography-Based Targeting in Deep Brain Stimulation for Psychiatric Indications

Deep Brain Stimulation (DBS) has been investigated as a treatment option for patients with refractory psychiatric illness. Over the past two decades, neuroimaging developments have helped to advance the field, particularly the use of diffusion tensor imaging (DTI) and tractographic reconstruction of...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2020-11, Vol.14, p.588423-588423
Main Authors: Davidson, Benjamin, Lipsman, Nir, Meng, Ying, Rabin, Jennifer S, Giacobbe, Peter, Hamani, Clement
Format: Article
Language:English
Subjects:
Deep brain stimulation
depression
diffusion tensor imaging
Electrodes
Illnesses
Magnetic resonance imaging
Medical imaging
Mental depression
Neuroimaging
Neuroscience
Neurosurgery
Obsessive compulsive disorder
Patients
Post traumatic stress disorder
Substantia alba
Surgery
tractography
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Summary:Deep Brain Stimulation (DBS) has been investigated as a treatment option for patients with refractory psychiatric illness. Over the past two decades, neuroimaging developments have helped to advance the field, particularly the use of diffusion tensor imaging (DTI) and tractographic reconstruction of white-matter pathways. In this article, we review translational considerations and how DTI and tractography have been used to improve targeting during DBS surgery for depression, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD).
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2020.588423