Cardiac function in relation to functional status and fatigue in patients with post-COVID syndrome

Patients with Post-COVID syndrome (PCS) are frequently referred for cardiologic evaluation. We assessed cardiac function and biomarkers in relation to functional status and fatigue in patients with PCS. This prospective single-center cohort study included 227 patients with persisting symptoms after...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.19575-10, Article 19575
Main Authors: Baum, Paul, Do, Lisa, Deterding, Lea, Lier, Julia, Kunis, Ines, Saur, Dorothee, Classen, Joseph, Wirtz, Hubert, Laufs, Ulrich
Format: Article
Language:English
Subjects:
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Biomarkers
Calcium-binding protein
Cardiac function
Cardiovascular diseases
Cognition
Cohort Studies
Comorbidity
COVID-19
COVID-19 - complications
Dyspnea
Fatigue
Fatigue - etiology
Functional Status
Heart
Humanities and Social Sciences
Humans
multidisciplinary
Prospective Studies
Respiration
Science
Science (multidisciplinary)
Stroke Volume
Troponin
Troponin T
Ventricle
Ventricular Function, Left
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Summary:Patients with Post-COVID syndrome (PCS) are frequently referred for cardiologic evaluation. We assessed cardiac function and biomarkers in relation to functional status and fatigue in patients with PCS. This prospective single-center cohort study included 227 patients with persisting symptoms after COVID-19 infection. Most frequent complaints were fatigue (70%), dyspnea (56%), neurocognitive symptoms (34%) and chest pain (28%). Standardized questionnaires were used to assess Post-COVID-Functional-Scale (PCFS) and fatigue (MFI-20). The fatigue severity was inversely related to age and did not correlate with cardiovascular diseases, echocardiographic findings, or biomarkers. Similarly, mild to moderate functional impairment (PCFS 1–3) did not correlate with cardiovascular alterations. However, the subgroup of patients with significant functional impairment (PCFS = 4) had more frequent cardiovascular comorbidities, biomarkers and impaired global longitudinal strain (GLS). Patients with elevated troponin T showed abnormal GLS, reduced left ventricular ejection fraction and impaired tricuspid annular plane systolic excursion. The majority of patients with PCS shows a normal cardiac function. Only the small subgroup of patients with severe functional impairment and patients with elevated troponin T is at risk for impaired cardiac function and likely to benefit from specialized care by a cardiologist.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24038-3