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"sCT-Feasibility" - a feasibility study for deep learning-based MRI-only brain radiotherapy

Radiotherapy (RT) is an important treatment modality for patients with brain malignancies. Traditionally, computed tomography (CT) images are used for RT treatment planning whereas magnetic resonance imaging (MRI) images are used for tumor delineation. Therefore, MRI and CT need to be registered, wh...

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Published in:Radiation oncology (London, England) England), 2024-03, Vol.19 (1), p.33-33, Article 33
Main Authors: Grigo, Johanna, Szkitsak, Juliane, Höfler, Daniel, Fietkau, Rainer, Putz, Florian, Bert, Christoph
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description Radiotherapy (RT) is an important treatment modality for patients with brain malignancies. Traditionally, computed tomography (CT) images are used for RT treatment planning whereas magnetic resonance imaging (MRI) images are used for tumor delineation. Therefore, MRI and CT need to be registered, which is an error prone process. The purpose of this clinical study is to investigate the clinical feasibility of a deep learning-based MRI-only workflow for brain radiotherapy, that eliminates the registration uncertainty through calculation of a synthetic CT (sCT) from MRI data. A total of 54 patients with an indication for radiation treatment of the brain and stereotactic mask immobilization will be recruited. All study patients will receive standard therapy and imaging including both CT and MRI. All patients will receive dedicated RT-MRI scans in treatment position. An sCT will be reconstructed from an acquired MRI DIXON-sequence using a commercially available deep learning solution on which subsequent radiotherapy planning will be performed. Through multiple quality assurance (QA) measures and reviews during the course of the study, the feasibility of an MRI-only workflow and comparative parameters between sCT and standard CT workflow will be investigated holistically. These QA measures include feasibility and quality of image guidance (IGRT) at the linear accelerator using sCT derived digitally reconstructed radiographs in addition to potential dosimetric deviations between the CT and sCT plan. The aim of this clinical study is to establish a brain MRI-only workflow as well as to identify risks and QA mechanisms to ensure a safe integration of deep learning-based sCT into radiotherapy planning and delivery. Compared to CT, MRI offers a superior soft tissue contrast without additional radiation dose to the patients. However, up to now, even though the dosimetrical equivalence of CT and sCT has been shown in several retrospective studies, MRI-only workflows have still not been widely adopted. The present study aims to determine feasibility and safety of deep learning-based MRI-only radiotherapy in a holistic manner incorporating the whole radiotherapy workflow. NCT06106997.
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The present study aims to determine feasibility and safety of deep learning-based MRI-only radiotherapy in a holistic manner incorporating the whole radiotherapy workflow. 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subjects Algorithms
Analysis
Artificial intelligence
Brain
Brain cancer
Brain tumors
Care and treatment
Computed tomography
Deep learning
Diagnosis
Dosimetry
Feasibility
Feasibility studies
Image quality
Immobilization
Machine learning
Magnetic resonance imaging
Medical imaging
Methods
MRI
MRI-only workflow
Neuroimaging
Patient outcomes
Patient positioning
Patients
Planning
Quality assurance
Radiation dosage
Radiation therapy
Radiotherapy
Registration
sCT
Soft tissues
Synthetic CT
Workflow
title "sCT-Feasibility" - a feasibility study for deep learning-based MRI-only brain radiotherapy
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