Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study

Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D level...

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Bibliographic Details
Published in:Asian journal of andrology 2015-03, Vol.17 (2), p.324-328
Main Authors: Tak, Young Jin, Lee, Jeong Gyu, Kim, Yun Jin, Park, Nam Cheol, Kim, Sang Soo, Lee, Sangyeoup, Cho, Byung Mann, Kong, Eun Hee, Jung, Dong Wook, Yi, Yu Hyeon
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
hypogonadism
seasons
testosterone
vitamin D
Adult
Aged
Aged, 80 and over
Aging - blood
Analysis
Biomarkers - blood
Cross-Sectional Studies
Eunuchism - blood
Eunuchism - diagnosis
Eunuchism - epidemiology
Humans
Incidence
Koreans
Linear Models
Male
Measurement
Middle Aged
Original
Physiological aspects
Republic of Korea - epidemiology
Seasons
Sunlight
Testosterone
Testosterone - blood
Testosterone - deficiency
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:Previous studies have demonstrated that male hypogonadism is associated with a low level of vitamin D. However, no reports have investigated the effects of vitamin D on testosterone levels in Korean men. Our aim was to investigate whether testosterone levels are associated with serum vitamin D levels and whether seasonal variation exists. This cross-sectional study analyzed serum 25-hydroxyvitamin D [25(OH)D], total testosterone (TT), and free testosterone (FT) in 652 Korean men over 40 years of age who had undergone a comprehensive medical examination. The average age of the subjects was 56.7 ± 7.9 years, and the mean serum 25(OH)D, TT and FT levels were 21.23 ± 7.9 ng ml-1 , 4.70 ± 1.6 ng ml-1 , and 8.12 ± 3.3 pg ml-1 , respectively. In the multiple linear regression model, 25(OH)D showed positive association with TT (β =0.137, P< 0.001) and FT (β =0.103, P= 0.008). 25(OH)D and FT showed similar seasonal or monthly variation after adjustment for age. A vitamin D deficiency [25(OH)D < 20 ng ml-1 ] was associated with an increased risk of deficiencies of TT (
ISSN:1008-682X
1745-7262
DOI:10.4103/1008-682X.142137