Phytochemical analysis and Enzyme Inhibition Assay of Aerva javanica for Ulcer

Background Aerva javanica (Burm. f.) Juss. ex Schult. (Amaranthacea) is traditionally used for the treatment of wound healings, cough, diarrhoea, ulcer and hyperglycaemia. The current study was aimed to fractionate and isolate bioactive compounds and ultimately to evaluate their anti-ulcereogenic po...

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Bibliographic Details
Published in:BMC chemistry 2012-07, Vol.6 (1), p.76-76, Article 76
Main Authors: Khan, Abdul Wajid, Jan, Saleem, Parveen, Shaista, Khan, Rahmat Ali, Saeed, Asma, Tanveer, Abdul Jabbar, Shad, Anwar Ali
Format: Article
Language:English
Subjects:
Aerva
Aerva javanica
Agriculture
Amides
Ammonia
Biological Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cough
Ethyl acetate fraction
Extraction
Fractionation
Inhibition
LSD
Lysergic acid diethylamide
Polarity
Purification
Research Article
Solvent-solvent extraction
Ulcers
Urease activity
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Summary:Background Aerva javanica (Burm. f.) Juss. ex Schult. (Amaranthacea) is traditionally used for the treatment of wound healings, cough, diarrhoea, ulcer and hyperglycaemia. The current study was aimed to fractionate and isolate bioactive compounds and ultimately to evaluate their anti-ulcereogenic potential. Results In order to achieve these aims, the fractionation, purifications and then biological potential determination of the isolated compounds was carried out. For purification purpose, initially extraction of the plant material was done with aqueous MeOH in the order of increasing polarity by using solvent-solvent extraction method. Phytochemical analysis revealed the presence of three compounds, 3-hydroxy-4 methoxybenzaldehyde ( 1 ), ursolic acid ( 2 ) and ( E )- N -(4-hydroxy-3-methoxyphenethyl)-3-(4-hydroxy-3-ethoxyphenyl) acryl amide ( 3 ). Inhibition of urease activity of various fractions revealed that ethyl acetate fraction showed significant activity ( P
ISSN:1752-153X
1752-153X
2661-801X
DOI:10.1186/1752-153X-6-76