Exosome, the glass slipper for Cinderella of cancer—bladder cancer?

Exosomes are lipid bilayer vesicles with a diameter of 40-100 nm secreted by almost all cells. They have been found play crucial regulatory roles in various diseases. With the development of exosomes engineering technology, exosome-based drug delivery has also rapidly evolved. Bladder cancer is a wo...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2023-10, Vol.21 (1), p.1-368, Article 368
Main Authors: Yang, Yuanyuan, Miao, Lintao, Lu, Yuchao, Sun, Yi, Wang, Shaogang
Format: Article
Language:English
Subjects:
Antigens
Biomedical engineering
Biosynthesis
Bladder
Bladder cancer
Breast cancer
Cancer
Care and treatment
Cell organelles
Clinical biomarker
Development and progression
Diagnosis
Drug delivery
Drug delivery systems
Drugs
Engineering
Exosome
Exosomes
Extracellular vesicles
Health aspects
Lipid bilayers
Lipids
Mass spectrometry
Mass spectroscopy
Mechanism
Metastasis
Morbidity
Next-generation sequencing
Oncology, Experimental
Peptides
Physiology
Plasma
Prognosis
Proteins
Review
Vehicles
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Summary:Exosomes are lipid bilayer vesicles with a diameter of 40-100 nm secreted by almost all cells. They have been found play crucial regulatory roles in various diseases. With the development of exosomes engineering technology, exosome-based drug delivery has also rapidly evolved. Bladder cancer is a worldwide disease with high morbidity and recurrence but lack of funding, so it is also called Cinderella. Some explorations have demonstrated that exosomes are important in the development, prognosis, diagnosis and drug delivery of bladder cancer. With the rapid development of Mass spectrometry and next-generation sequencing, increasing numbers of differentially expressed molecules derived from exosomes have been found in bladder cancer. Exosomes and their contents are largely involved in bladder cancer progression, engineering of these exosomes with the targeted genes improves their potential for drug delivery of bladder cancer. Furthermore, exosomes and their contents are relate to many characteristics of bladder cancer. Herein, we briefly search 59 researches to explore the cargoes encapsuled in exosomes of bladder cancer patients. We also summarize the biogenesis, function, expression profiles, engineering approaches and biological mechanisms of exosomes and their contents for the diagnosis, prognosis and drug delivery for bladder cancer. We aim to make it clear whether exosomes are the glass slippers of Cinderella.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-023-02130-8