A novel zinc complex with antibacterial and antioxidant activity

Background In order to enhance the antibacterial activity and reduce the toxicity of Zn 2+ , novel complexes of Zn(II) were synthesized. Results A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acu...

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Bibliographic Details
Published in:BMC chemistry 2021-03, Vol.15 (1), p.17-17, Article 17
Main Authors: Zhang, Yun, Li, Xiaojing, Li, Jia, Khan, Md. Zaved Hossain, Ma, Fanyi, Liu, Xiuhua
Format: Article
Language:English
Subjects:
Absorption
Antibacterial activity
Antioxidants
Characterization
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
E coli
Fluorescence
Glucose
Hydrogen bonding
Morphology
Research Article
Structural analysis
Synthesis
Toxicity testing
Zinc chloride
Zinc compounds
Zinc-glucose-citrate complex
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Summary:Background In order to enhance the antibacterial activity and reduce the toxicity of Zn 2+ , novel complexes of Zn(II) were synthesized. Results A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl 2 , ZnGC complex presented better antibacterial activity against Staphylococcus aureus ( S. aureus , Gram-positive) and Escherichia coli ( E. coli , Gram-negative). Conclusions The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.
ISSN:2661-801X
2661-801X
DOI:10.1186/s13065-021-00745-2