Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study

Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors. Patients with an initial di...

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Bibliographic Details
Published in:Annals of medicine (Helsinki) 2024-12, Vol.56 (1), p.2323097
Main Authors: He, Xing, Ji, Jiaqi, Pei, Zongmin, Luo, Zeli, Fang, Siyu, Liu, Xiaoqin, Lei, Yan, Yan, Haiying, Guo, Lu
Format: Article
Language:English
Subjects:
antifibrotic therapy
anxiety
Anxiety - complications
Anxiety - drug therapy
Anxiety - epidemiology
Anxiety Disorders - complications
Anxiety Disorders - drug therapy
Anxiety Disorders - epidemiology
depression
Depression - complications
Depression - drug therapy
Depression - epidemiology
Humans
Idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis - complications
Idiopathic Pulmonary Fibrosis - drug therapy
Idiopathic Pulmonary Fibrosis - epidemiology
Indoles
Medically Unexplained Symptoms
Pulmonary Medicine
Quality of Life
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Summary:Anxiety and depression are common comorbidities in idiopathic pulmonary fibrosis (IPF) that impair health-related quality of life. However, there is a lack of studies focusing on the mental disorder of IPF after antifibrotic treatment and their related predictive factors. Patients with an initial diagnosis of IPF were enrolled. Data on demographics, lung function, Generalized Anxiety Disorder-7 (GAD-7) Scale, Patient Health Questionnaire 9 (PHQ-9), Patient Health Questionnaire-15 (PHQ-15), and St. George's Respiratory Questionnaire total score(SGRQ-T) were collected. Changes in anxiety, depression, somatic symptoms, and quality of life scores before and after nintedanib treatment were compared, and the related predictive factors were analyzed. A total of 56 patients with a first diagnosis of IPF were enrolled, with 42 and 35 patients suffering from anxiety and depression, respectively. The GAD-7, PHQ-9, PHQ-15, and SGRQ scores were higher in the anxiety and depression groups. SGRQ total score (SGRQ-T) [OR = 1.075, 95%CI= (1.011, 1.142)] was an independent predictor of IPF combined with anxiety (  
ISSN:0785-3890
1365-2060
1365-2060
DOI:10.1080/07853890.2024.2323097