Glucose tolerance in Canadian and French cystic fibrosis adult patients

Cystic fibrosis (CF)-related diabetes is associated with increased mortality. We analysed the clinical and glycemic profiles of two cohorts of patients treated according to the same guidelines in France and Canada. To investigate incidence differences in phenotypic and glucose abnormalities and to e...

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.4763-4763, Article 4763
Main Authors: Reynaud, Quitterie, Boudreau, Valérie, Touzet, Sandrine, Desjardins, Katherine, Bourdy, Stéphanie Poupon, Blond, Emilie, Berthiaume, Yves, Rabasa-Lhoret, Rémi, Durieu, Isabelle
Format: Article
Language:English
Subjects:
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692/699
Adult
Blood
Blood Glucose - analysis
Body Mass Index
Canada
Chromium
Cystic fibrosis
Cystic Fibrosis - pathology
Diabetes
Diabetes mellitus
Diabetes Mellitus - mortality
Diabetes Mellitus - pathology
Female
Forced Expiratory Flow Rates - physiology
France
Glucose
Glucose Intolerance - pathology
Glucose tolerance
Glucose Tolerance Test
Humanities and Social Sciences
Humans
Insulin - blood
Life Sciences
Lungs
Male
multidisciplinary
Respiratory function
Science
Science (multidisciplinary)
Sex ratio
Young Adult
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Summary:Cystic fibrosis (CF)-related diabetes is associated with increased mortality. We analysed the clinical and glycemic profiles of two cohorts of patients treated according to the same guidelines in France and Canada. To investigate incidence differences in phenotypic and glucose abnormalities and to explore the evolution over a 4-year follow-up period, two cohorts of 224 Canadian and 147 French adult CF patients (≥18 years) without treated CF-related diabetes (CFRD) were followed over a 4 year period. In each of these groups, we investigated the longitudinal relationship between glucose tolerance and pulmonary function. An annual 2-hour oral glucose tolerance test was performed: fasting blood glucose (G0) and 2-h blood glucose (G2) were measured. Patients were classified at inclusion according to their glucose tolerance status: Normal glucose tolerant, abnormal glucose tolerant or de novo CFRD. Age, sex ratio and proportion of F508del homozygous patients were not statistically different between both cohorts. Canadian patients had better pulmonary function (median %FEV1 (IQR): 71.0 (55.0–82.0) vs. 64.0 (40.0–78.0), p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-40592-9