The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice

Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies. The purpose of the present paper is to compare protective effects of alpha-, beta-, and gamma-melanocyte stimulat...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2010-03, Vol.15 (3), p.1232-1241
Main Authors: Blagaić, Vladimir, Houra, Karlo, Turcić, Petra, Stambuk, Nikola, Konjevoda, Pasko, Boban-Blagaić, Alenka, Kelava, Tomislav, Kos, Marina, Aralica, Gorana, Culo, Filip
Format: Article
Language:English
Subjects:
acetaminophen
Acetaminophen - toxicity
Adrenocorticotropic Hormone - chemistry
Alanine Transaminase - blood
alpha-MSH
alpha-MSH - chemistry
alpha-MSH - pharmacology
Amino Acid Sequence
Animals
Aspartate Aminotransferases - blood
beta-MSH
beta-MSH - chemistry
beta-MSH - pharmacology
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - prevention & control
Dose-Response Relationship, Drug
gamma-MSH
gamma-MSH - chemistry
gamma-MSH - pharmacology
liver
Male
melanocortins
Mice
Mice, Inbred CBA
Molecular Sequence Data
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Summary:Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies. The purpose of the present paper is to compare protective effects of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that alpha-, beta-, and gamma-MSH decrease intensity of lesions by both criteria in a dose-dependent manner.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules15031232