Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels

Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecol...

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Bibliographic Details
Published in:BMC medical genetics 2009-03, Vol.10 (1), p.30-30, Article 30
Main Authors: Domanska, Katarina, Carlsson, Christina, Bendahl, Pär-Ola, Nilbert, Mef
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Basic Medicine
Cancer
Care and treatment
Clinical Competence
Colorectal cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Female
Genetic aspects
Genetic Carrier Screening
Genetic Predisposition to Disease
Genetic screening
Genetic Testing
Health aspects
Humans
Male
Medical and Health Sciences
Medical Genetics
Medicin och hälsovetenskap
Medicinsk genetik
Medicinska och farmaceutiska grundvetenskaper
Methods
Middle Aged
Mutation
Physicians
Practice
Risk Assessment
Risk factors
Surveys and Questionnaires
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Summary:Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology. Data were collected using a questionnaire which was answered by 67 mutation carriers and 102 physicians from the southern Swedish health care region. The statements were related to colorectal cancer, heredity and surveillance and the physicians were also asked questions about cancer risks and surveillance strategies. Both groups answered questions on colorectal cancer risk, surveillance and genetic testing well, whereas answers about inheritance and risks for HNPCC associated cancer were less accurate. Only half of the family members and one third of the physicians correctly estimated the risk to inherit an HNPCC predisposing mutation. Among family members, young age (
ISSN:1471-2350
1471-2350
DOI:10.1186/1471-2350-10-30