Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement

The bioresource (>265 patients with >27,600 biospecimens until December 2019; recruitment ongoing) on severe aortic stenosis is of vital importance to improve the still incomplete understanding of its etiology as well as its transition to heart failure. The bioresource contains various biospec...

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Bibliographic Details
Published in:Open journal of bioresources 2020-03, Vol.7 (9540)
Main Authors: Beuthner, Bo E. C, Topci, Rodi, Derks, Mareike, Franke, Thomas, Seelke, Sandra, Puls, Miriam, Schuster, Andreas, Toischer, Karl, Valentova, Miroslava, Cyganek, Lukas, Zeisberg, Elisabeth M, Jacobshagen, Claudius, Hasenfuss, Gerd, Nussbeck, Sara Y
Format: Article
Language:English
Subjects:
Aortic valve stenosis
biobank
cardiac mri
Cardiovascular research
CAT scans
Development and progression
Diagnostic imaging
Echocardiography
EDTA
Etiology (Medicine)
Healthcare industry software
Heart cells
Heart failure
Heart valve diseases
human fibroblasts
Information management
Interdisciplinary research
left-ventricular cardiomyocytes
Medical imaging equipment
microbiome
Scientific equipment industry
Skin
Stem cells
Stenosis
Tomography
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Summary:The bioresource (>265 patients with >27,600 biospecimens until December 2019; recruitment ongoing) on severe aortic stenosis is of vital importance to improve the still incomplete understanding of its etiology as well as its transition to heart failure. The bioresource contains various biospecimens, standardised clinical and imaging data sets including transthoracic echocardiography, computed tomography and magnetic resonance imaging of the heart. Biospecimen sampling follows the SOP-driven collection scheme of the German Center for Cardiovascular Research (DZHK) for venous blood and urine [1]. In addition, left-ventricular endomyocardial biopsies, rectal swabs and skin biopsies (for subsequent generation of induced pluripotent stem cells) are collected. Data management includes the use of a professional biospecimen management system as well as a Picture Archiving and Communication System (PACS) for imaging data. A Good Clinical Practice (GCP)-conform software for the management of clinical data and a trusted third party for the management of patient identifying data and pseudonyms are in place. Given these conditions, there is a high reuse-potential for biospecimens and data. Keywords: Heart failure, aortic valve stenosis, biobank, cardiac MRI, echocardiography, left-ventricular cardiomyocytes, human fibroblasts, microbiome
ISSN:2056-5542
2056-5542
DOI:10.5334/ojb.65