Immunomodulatory Effects of Histone Deacetylation Inhibitors in Graft-vs.-Host Disease After Allogeneic Stem Cell Transplantation

Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress immune-mediated diseases, such as graft-vs.-host...

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Bibliographic Details
Published in:Frontiers in immunology 2021-02, Vol.12, p.641910-641910
Main Authors: Xu, Xiaoxiao, Li, Xiaoqin, Zhao, Yanmin, Huang, He
Format: Article
Language:English
Subjects:
allo-reactive T cells
allogeneic hematopoietic stem cell transplantation
epigenetic regulation
graft-vs.-host disease
histone deacetylase inhibitors
Immunology
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Summary:Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress immune-mediated diseases, such as graft-vs.-host disease (GVHD), while retaining beneficial graft-vs.-leukemia (GVL) effects. These drugs prevent and/or treat GVHD by modifying gene expression and inhibiting the production of proinflammatory cytokines, regulating the function of alloreactive T cells, and upregulating the function and number of regulatory T cells. Some of these drugs may become new immunotherapies for GVHD and other immune diseases.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.641910