Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii

Four new indolediketopiperazine derivatives ( - ), along with nine known congeners ( - ), were isolated and identified from the culture extract of EN-220, an endophytic fungus obtained from the marine alga . The structures of thesecompounds were elucidated on the basis of extensive spectroscopic ana...

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Bibliographic Details
Published in:Marine drugs 2017-01, Vol.15 (2), p.24-24
Main Authors: Du, Feng-Yu, Li, Xin, Li, Xiao-Ming, Zhu, Li-Wei, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Aquatic Organisms - chemistry
Aquatic Organisms - microbiology
Artemia - drug effects
Artemia salina
bioactivity
Circular Dichroism - methods
Decapoda
endophytic fungus
Eurotium
Eurotium - chemistry
Eurotium cristatum
Fungi - chemistry
indolediketopiperazine
Marine
marine alga
Microbial Sensitivity Tests - methods
Penaeidae
Sargassum - chemistry
Sargassum - microbiology
Sargassum thunbergii
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Summary:Four new indolediketopiperazine derivatives ( - ), along with nine known congeners ( - ), were isolated and identified from the culture extract of EN-220, an endophytic fungus obtained from the marine alga . The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds - were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp ( ) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15020024