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Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii
Four new indolediketopiperazine derivatives ( - ), along with nine known congeners ( - ), were isolated and identified from the culture extract of EN-220, an endophytic fungus obtained from the marine alga . The structures of thesecompounds were elucidated on the basis of extensive spectroscopic ana...
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| Published in: | Marine drugs 2017-01, Vol.15 (2), p.24-24 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33 |
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| cites | cdi_FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33 |
| container_end_page | 24 |
| container_issue | 2 |
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| container_title | Marine drugs |
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| creator | Du, Feng-Yu Li, Xin Li, Xiao-Ming Zhu, Li-Wei Wang, Bin-Gui |
| description | Four new indolediketopiperazine derivatives (
-
), along with nine known congeners (
-
), were isolated and identified from the culture extract of
EN-220, an endophytic fungus obtained from the marine alga
. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds
-
were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in
of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (
) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency. |
| doi_str_mv | 10.3390/md15020024 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_eac20fc52ee144b88e441efdddfe4b09</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_eac20fc52ee144b88e441efdddfe4b09</doaj_id><sourcerecordid>1881753196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33</originalsourceid><addsrcrecordid>eNqNks1u1DAQgCMEoqVw4QFQJC4IEfBv7FyQqmoLKxU4AGdrEo-z3ibxYidI5Ql4bLxsKS0nTh7NfP40M5qieErJa84b8ma0VBJGCBP3imNa16TKaXX_VnxUPEppSwiXuhEPiyOmKZOEsuPi53qyYUDrL3EOO7_DCD_8hOXpcAlD8DaVLoaxXC0xzH4Zyy76NMOco9XHijHyqoSpXGXHbnM1-648X6Z-SeU6hQFmtIff8wbLDxAP3h7KzxB7SGnZV5apxdh7_7h44GBI-OT6PSm-nq--nL2vLj69W5-dXlSdJHKuNJVOI3NcKW41tEpKQmjbIEHlHBdd42qLskMnOoagHFXaCQBrbQMUOT8p1gevDbA1u-hHiFcmgDe_EyH2BmKeZECD0DHiOskQqRCt1igERZdVDkVLmux6e3DtlnZE2-E0RxjuSO9WJr8xffhuJOeiJjILXlwLYvi2YJrN6FOHwwAThiUZqjVVktOm_g-0ZkwzUu_bev4Pug1LnPJWM6W0oFIJlamXB6qLIaWI7qZvSsz-rszfu8rws9uT3qB_Don_Aqxryzs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1878415747</pqid></control><display><type>article</type><title>Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Du, Feng-Yu ; Li, Xin ; Li, Xiao-Ming ; Zhu, Li-Wei ; Wang, Bin-Gui</creator><creatorcontrib>Du, Feng-Yu ; Li, Xin ; Li, Xiao-Ming ; Zhu, Li-Wei ; Wang, Bin-Gui</creatorcontrib><description>Four new indolediketopiperazine derivatives (
-
), along with nine known congeners (
-
), were isolated and identified from the culture extract of
EN-220, an endophytic fungus obtained from the marine alga
. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds
-
were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in
of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (
) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.</description><identifier>ISSN: 1660-3397</identifier><identifier>EISSN: 1660-3397</identifier><identifier>DOI: 10.3390/md15020024</identifier><identifier>PMID: 28125012</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alkaloids - pharmacology ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Aquatic Organisms - chemistry ; Aquatic Organisms - microbiology ; Artemia - drug effects ; Artemia salina ; bioactivity ; Circular Dichroism - methods ; Decapoda ; endophytic fungus ; Eurotium ; Eurotium - chemistry ; Eurotium cristatum ; Fungi - chemistry ; indolediketopiperazine ; Marine ; marine alga ; Microbial Sensitivity Tests - methods ; Penaeidae ; Sargassum - chemistry ; Sargassum - microbiology ; Sargassum thunbergii</subject><ispartof>Marine drugs, 2017-01, Vol.15 (2), p.24-24</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33</citedby><cites>FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1878415747/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1878415747?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28125012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Feng-Yu</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Li, Xiao-Ming</creatorcontrib><creatorcontrib>Zhu, Li-Wei</creatorcontrib><creatorcontrib>Wang, Bin-Gui</creatorcontrib><title>Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii</title><title>Marine drugs</title><addtitle>Mar Drugs</addtitle><description>Four new indolediketopiperazine derivatives (
-
), along with nine known congeners (
-
), were isolated and identified from the culture extract of
EN-220, an endophytic fungus obtained from the marine alga
. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds
-
were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in
of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (
) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.</description><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Aquatic Organisms - chemistry</subject><subject>Aquatic Organisms - microbiology</subject><subject>Artemia - drug effects</subject><subject>Artemia salina</subject><subject>bioactivity</subject><subject>Circular Dichroism - methods</subject><subject>Decapoda</subject><subject>endophytic fungus</subject><subject>Eurotium</subject><subject>Eurotium - chemistry</subject><subject>Eurotium cristatum</subject><subject>Fungi - chemistry</subject><subject>indolediketopiperazine</subject><subject>Marine</subject><subject>marine alga</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Penaeidae</subject><subject>Sargassum - chemistry</subject><subject>Sargassum - microbiology</subject><subject>Sargassum thunbergii</subject><issn>1660-3397</issn><issn>1660-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNks1u1DAQgCMEoqVw4QFQJC4IEfBv7FyQqmoLKxU4AGdrEo-z3ibxYidI5Ql4bLxsKS0nTh7NfP40M5qieErJa84b8ma0VBJGCBP3imNa16TKaXX_VnxUPEppSwiXuhEPiyOmKZOEsuPi53qyYUDrL3EOO7_DCD_8hOXpcAlD8DaVLoaxXC0xzH4Zyy76NMOco9XHijHyqoSpXGXHbnM1-648X6Z-SeU6hQFmtIff8wbLDxAP3h7KzxB7SGnZV5apxdh7_7h44GBI-OT6PSm-nq--nL2vLj69W5-dXlSdJHKuNJVOI3NcKW41tEpKQmjbIEHlHBdd42qLskMnOoagHFXaCQBrbQMUOT8p1gevDbA1u-hHiFcmgDe_EyH2BmKeZECD0DHiOskQqRCt1igERZdVDkVLmux6e3DtlnZE2-E0RxjuSO9WJr8xffhuJOeiJjILXlwLYvi2YJrN6FOHwwAThiUZqjVVktOm_g-0ZkwzUu_bev4Pug1LnPJWM6W0oFIJlamXB6qLIaWI7qZvSsz-rszfu8rws9uT3qB_Don_Aqxryzs</recordid><startdate>20170125</startdate><enddate>20170125</enddate><creator>Du, Feng-Yu</creator><creator>Li, Xin</creator><creator>Li, Xiao-Ming</creator><creator>Zhu, Li-Wei</creator><creator>Wang, Bin-Gui</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>M7N</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170125</creationdate><title>Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii</title><author>Du, Feng-Yu ; Li, Xin ; Li, Xiao-Ming ; Zhu, Li-Wei ; Wang, Bin-Gui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-815f8e2f3773d8ab755001b9e0e7ff34c9f6de5cef4c2ea7f178f4aaddd9a1e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Aquatic Organisms - chemistry</topic><topic>Aquatic Organisms - microbiology</topic><topic>Artemia - drug effects</topic><topic>Artemia salina</topic><topic>bioactivity</topic><topic>Circular Dichroism - methods</topic><topic>Decapoda</topic><topic>endophytic fungus</topic><topic>Eurotium</topic><topic>Eurotium - chemistry</topic><topic>Eurotium cristatum</topic><topic>Fungi - chemistry</topic><topic>indolediketopiperazine</topic><topic>Marine</topic><topic>marine alga</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Penaeidae</topic><topic>Sargassum - chemistry</topic><topic>Sargassum - microbiology</topic><topic>Sargassum thunbergii</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Feng-Yu</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Li, Xiao-Ming</creatorcontrib><creatorcontrib>Zhu, Li-Wei</creatorcontrib><creatorcontrib>Wang, Bin-Gui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oceanic Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJÂ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Feng-Yu</au><au>Li, Xin</au><au>Li, Xiao-Ming</au><au>Zhu, Li-Wei</au><au>Wang, Bin-Gui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2017-01-25</date><risdate>2017</risdate><volume>15</volume><issue>2</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Four new indolediketopiperazine derivatives (
-
), along with nine known congeners (
-
), were isolated and identified from the culture extract of
EN-220, an endophytic fungus obtained from the marine alga
. The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds
-
were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in
of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp (
) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28125012</pmid><doi>10.3390/md15020024</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-3397 |
| ispartof | Marine drugs, 2017-01, Vol.15 (2), p.24-24 |
| issn | 1660-3397 1660-3397 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_eac20fc52ee144b88e441efdddfe4b09 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Alkaloids - pharmacology Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Aquatic Organisms - chemistry Aquatic Organisms - microbiology Artemia - drug effects Artemia salina bioactivity Circular Dichroism - methods Decapoda endophytic fungus Eurotium Eurotium - chemistry Eurotium cristatum Fungi - chemistry indolediketopiperazine Marine marine alga Microbial Sensitivity Tests - methods Penaeidae Sargassum - chemistry Sargassum - microbiology Sargassum thunbergii |
| title | Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii |
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