Wickerhamomyces Yeast Killer Toxins' Medical Applications

Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by and other related species. A perspective on the applications of these KTs in the medical field...

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Bibliographic Details
Published in:Toxins 2021-09, Vol.13 (9), p.655
Main Authors: Giovati, Laura, Ciociola, Tecla, De Simone, Tiziano, Conti, Stefania, Magliani, Walter
Format: Article
Language:English
Subjects:
Anti-Infective Agents - therapeutic use
Anti-Infective Agents - toxicity
Antiinfectives and antibacterials
antimicrobial activity
Antimicrobial agents
Arthropods
Bacteria
Cell cycle
Chemical compounds
Communicable Diseases - drug therapy
Cytotoxins - therapeutic use
Food
Humans
Immunology
Infectious diseases
Killer Factors, Yeast - therapeutic use
Killer Factors, Yeast - toxicity
killer toxins
killer yeasts
medical applications
Microorganisms
Parasites
Pathogens
Pharmacology
Review
Saccharomycetales - chemistry
Toxins
Vaccine Development
Wickerhamomyces anomalus
Yeast
Yeasts
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Summary:Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins13090655