Association of Skeletal Muscle and Adipose Tissue Distribution with Histologic Severity of Non-Alcoholic Fatty Liver

Adipose tissue and skeletal muscle is associated with non-alcoholic fatty liver disease (NAFLD). This study evaluates the association between body composition and histologic severity in patients with NAFLD. Using the cross-sectional CT images at the level of L3 vertebra and the histologic findings o...

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Bibliographic Details
Published in:Diagnostics (Basel) 2021-06, Vol.11 (6), p.1061
Main Authors: Kang, Min-Kyu, Baek, Jung-Hun, Kweon, Young-Oh, Tak, Won-Young, Jang, Se-Young, Lee, Yu-Rim, Hur, Keun, Kim, Gyeonghwa, Lee, Hye-Won, Han, Man-Hoon, Choi, Joon-Hyuk, Park, Soo-Young, Park, Jung-Gil
Format: Article
Language:English
Subjects:
Abdomen
adipose tissue
Biopsy
Body composition
Body fat
Comparative analysis
Diabetes
Hospitals
Inflammation
Laboratories
Liver diseases
Medical imaging
Musculoskeletal system
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Obesity
Sarcopenia
skeletal muscle
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Summary:Adipose tissue and skeletal muscle is associated with non-alcoholic fatty liver disease (NAFLD). This study evaluates the association between body composition and histologic severity in patients with NAFLD. Using the cross-sectional CT images at the level of L3 vertebra and the histologic findings of 178 patients with biopsy-proven NAFLD, we analyzed the correlation of the histologic findings to the skeletal muscle index (SMI), subcutaneous adipose tissue index (SATI), and visceral adipose tissue index (VATI), which is defined as the body composition area (cm2) by height squared (m2). The clinical and laboratory features with body composition were analyzed to determine the risk factors for advanced fibrosis. The VATI significantly increased in severe non-alcoholic steatohepatitis (NASH) or advanced fibrosis. In addition, the VATI was correlated with the NAFLD activity score (NAS) and the fibrosis stage. In multivariate analyses, age (odds ratio (OR), 1.09; 95% confidence interval (CI), 1.02–1.19; p = 0.025), severe NASH (OR, 8.66; 95% CI, 2.13–46.40; p = 0.005), and visceral adiposity (OR, 6.77; 95% CI, 1.81–29.90; p = 0.007) were independently associated with advanced fibrosis in patients with NAFLD. Visceral adiposity is correlated with the histologic severity of NAFLD, which is independently associated with advanced fibrosis.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11061061