Mitochondrial gene expression signature predicts prognosis of pediatric acute myeloid leukemia patients

Gene expression profile of mitochondrial-related genes is not well deciphered in pediatric acute myeloid leukaemia (AML). We aimed to identify mitochondria-related differentially expressed genes (DEGs) in pediatric AML with their prognostic significance. Children with AML were included prospectively...

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Bibliographic Details
Published in:Frontiers in oncology 2023-02, Vol.13, p.1109518-1109518
Main Authors: Chaudhary, Shilpi, Ganguly, Shuvadeep, Palanichamy, Jayanth Kumar, Singh, Archna, Pradhan, Dibyabhaba, Bakhshi, Radhika, Chopra, Anita, Bakhshi, Sameer
Format: Article
Language:English
Subjects:
acute myeloid leukema
child
gene signature
mitochondria
Oncology
RNA sequencing
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Summary:Gene expression profile of mitochondrial-related genes is not well deciphered in pediatric acute myeloid leukaemia (AML). We aimed to identify mitochondria-related differentially expressed genes (DEGs) in pediatric AML with their prognostic significance. Children with AML were included prospectively between July 2016-December 2019. Transcriptomic profiling was done for a subset of samples, stratified by mtDNA copy number. Top mitochondria-related DEGs were identified and validated by real-time PCR. A prognostic gene signature risk score was formulated using DEGs independently predictive of overall survival (OS) in multivariable analysis. Predictive ability of the risk score was estimated along with external validation in The Tumor Genome Atlas (TCGA) AML dataset. In 143 children with AML, twenty mitochondria-related DEGs were selected for validation, of which 16 were found to be significantly dysregulated. Upregulation of (p
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1109518