Statins in Chronic Kidney Disease-Effects on Atherosclerosis and Cellular Senescence

• Published in: Cells (Basel, Switzerland) Switzerland), 2023-06, Vol.12 (13), p.1679
• Main Authors: Fularski, Piotr, Krzemińska, Julia, Lewandowska, Natalia, Młynarska, Ewelina, Saar, Maciej, Wronka, Magdalena, Rysz, Jacek, Franczyk, Beata
• Format: Article
• Language: English
• Subjects: Age; Aging; Antioxidants; Arteriosclerosis; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - etiology; Calcification; Cardiovascular diseases; Cardiovascular Diseases - complications; Cell cycle; Cells; Cellular Senescence; Cholesterol; chronic kidney disease; Chronic kidney failure; Complications and side effects; DNA damage; Dosage and administration; Drug therapy; Endothelial Cells; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Inflammation; Inflammation - complications; Kidney diseases; Lipid metabolism; Lipids; Macrophages; Mitochondrial DNA; Mortality; Nitric oxide; Oxidation; Oxidative stress; Patients; Reactive oxygen species; Renal failure; Renal function; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - drug therapy; Review; Risk factors; Senescence; Smooth muscle; Statins
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12131679

Chronic kidney disease (CKD) is a serious health problem that can affect various systems in the human body. Renal failure promotes mechanisms of premature cellular aging and also features of generalized inflammation in the body, which translates into a close relationship between kidney dysfunction and cardiovascular disease (CVD). As kidney function deteriorates, cardiovascular risk and mortality increase in this group of patients. Oxidative stress and inflammation are two closely related processes that initiate a vicious cycle by activating each other. Together with aging, they represent the key factors that cause and exacerbate CVD in CKD. Patients with CKD are particularly vulnerable to the accumulation of aging endothelial cells, vascular smooth muscle and macrophages, increasing the risk of atherosclerosis. Several mechanisms are known that can lead to the progression of the aforementioned problems, such as the accumulation of uremic toxins, persistent inflammation, impaired lipid and electrolyte metabolism, nitric oxide (NO) deficiency, the increased production of reactive oxygen species (ROS) and damage to deoxyribonucleic acid (DNA) and mitochondria. According to research, we can distinguish a group of drugs that effectively counteract the negative effects of CKD-statins. This is a group of drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase and affect a number of cellular processes and pathways, resulting in the overall slowing of atherosclerosis and cellular aging.