Firing Frequency Maxima of Fast-Spiking Neurons in Human, Monkey, and Mouse Neocortex

Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording i...

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Published in:Frontiers in cellular neuroscience 2016-10, Vol.10, p.239-239
Main Authors: Wang, Bo, Ke, Wei, Guang, Jing, Chen, Guang, Yin, Luping, Deng, Suixin, He, Quansheng, Liu, Yaping, He, Ting, Zheng, Rui, Jiang, Yanbo, Zhang, Xiaoxue, Li, Tianfu, Luan, Guoming, Lu, Haidong D, Zhang, Mingsha, Zhang, Xiaohui, Shu, Yousheng
Format: Article
Language:English
Subjects:
Animal cognition
Brain research
Brain slice preparation
Cortex (entorhinal)
Cortex (frontal)
Cortex (temporal)
cortical interneuron
Epilepsy
fast-spiking neurons
Firing pattern
Firing rate
Humans
Laboratories
maximal firing frequency
monkey
Mouse
Neurogenesis
Neurons
Neuroscience
Neurosciences
Physiology
Sucrose
Visual cortex
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Summary:Cortical fast-spiking (FS) neurons generate high-frequency action potentials (APs) without apparent frequency accommodation, thus providing fast and precise inhibition. However, the maximal firing frequency that they can reach, particularly in primate neocortex, remains unclear. Here, by recording in human, monkey, and mouse neocortical slices, we revealed that FS neurons in human association cortices (mostly temporal) could generate APs at a maximal mean frequency (F ) of 338 Hz and a maximal instantaneous frequency (F ) of 453 Hz, and they increase with age. The maximal firing frequency of FS neurons in the association cortices (frontal and temporal) of monkey was even higher (F 450 Hz, F 611 Hz), whereas in the association cortex (entorhinal) of mouse it was much lower (F 215 Hz, F 342 Hz). Moreover, FS neurons in mouse primary visual cortex (V1) could fire at higher frequencies (F 415 Hz, F 582 Hz) than those in association cortex. We further validated our data by examining spikes of putative FS neurons in behaving monkey and mouse. Together, our results demonstrate that the maximal firing frequency of FS neurons varies between species and cortical areas.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2016.00239