Ginger Extract Ameliorates Obesity and Inflammation via Regulating MicroRNA-21/132 Expression and AMPK Activation in White Adipose Tissue

Ginger is a plant whose rhizome is used as a spice or folk medicine. We aimed to investigate the effect of ginger root extract on obesity and inflammation in rats fed a high-fat diet. Sprague-Dawley rats were divided into three groups and fed either a 45% high-fat diet (HF), HF + hot-water extract o...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2018-10, Vol.10 (11), p.1567
Main Authors: Kim, Seunghae, Lee, Mak-Soon, Jung, Sunyoon, Son, Hye-Yeon, Park, Seonyoung, Kang, Bori, Kim, Seog-Young, Kim, In-Hwan, Kim, Chong-Tai, Kim, Yangha
Format: Article
Language:English
Subjects:
Adipose Tissue, White - metabolism
AMP-Activated Protein Kinase Kinases
AMPK
Animals
Down-Regulation
Gene Expression Regulation - drug effects
ginger extract
Humans
inflammation
Inflammation - drug therapy
Inflammation - metabolism
microRNA-132
microRNA-21
MicroRNAs - metabolism
obesity
Obesity - drug therapy
Obesity - metabolism
Plant Extracts - chemistry
Plant Extracts - therapeutic use
Protein Kinases - genetics
Protein Kinases - metabolism
Rats, Sprague-Dawley
Zingiber officinale
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ginger is a plant whose rhizome is used as a spice or folk medicine. We aimed to investigate the effect of ginger root extract on obesity and inflammation in rats fed a high-fat diet. Sprague-Dawley rats were divided into three groups and fed either a 45% high-fat diet (HF), HF + hot-water extract of ginger (WEG; 8 g/kg diet), or HF + high-hydrostatic pressure extract of ginger (HPG; 8 g/kg diet) for 10 weeks. The HPG group had lower body weight and white adipose tissue (WAT) mass compared to the HF group. Serum and hepatic lipid levels of HPG group were lower, while fecal lipid excretion of the HPG group was higher than that of the HF group. In the WAT of the WEG and HPG groups, mRNA levels of adipogenic genes were lower than those of the HF group. Moreover, HPG group had lower mRNA levels of pro-inflammatory cytokines than did the HF group. MicroRNA (miR)-21 expression was down-regulated by both WEG and HPG. Additionally, miR-132 expression was down-regulated by HPG. The adenosine monophosphate-activated protein kinase (AMPK) activity of HPG group was greater than that of the HF group. HPG may have beneficial effects on obesity and inflammation, partially mediated by regulation of miR-21/132 expression and AMPK activation in WAT.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10111567