Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches

The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This r...

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Bibliographic Details
Published in:Oman medical journal 2010-04, Vol.25 (2), p.70-78
Main Authors: Philip , Betty, Philip , Anil K
Format: Article
Language:English
Subjects:
COLITIS
DRUGS
ENTERITIS
Review
SIDE EFFECTS
THERAPEUTIC STRATEGIES
إلتهاب الأمعاء
إلتهاب القولون
الأدوية
الأعراض الجانبية
الإستراتيجية العلاجية
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Summary:The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.
ISSN:1999-768X
2070-5204
2070-5204
DOI:10.5001/omj.2010.24