Antimicrobial and P450 inhibitory properties of common functional foods

To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for th...

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Bibliographic Details
Published in:Journal of pharmacy & pharmaceutical sciences 2014-01, Vol.17 (2), p.254-265
Main Authors: Nguyen, San, Huang, Huang, Foster, Brian C, Tam, Teresa W, Xing, Tim, Smith, Myron L, Arnason, John T, Akhtar, Humayoun
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Apiaceae - chemistry
Apium graveolens - chemistry
Cuminum - chemistry
Cytochrome P-450 Enzyme Inhibitors - chemistry
Cytochrome P-450 Enzyme Inhibitors - isolation & purification
Cytochrome P-450 Enzyme Inhibitors - pharmacology
Cytochrome P-450 Enzyme System - metabolism
Dose-Response Relationship, Drug
Foeniculum - chemistry
Functional Food
Humans
Lamiaceae - chemistry
Microbial Sensitivity Tests
Ocimum basilicum - chemistry
Origanum - chemistry
Seeds - chemistry
Structure-Activity Relationship
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Summary:To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora. The highest CYP inhibitory activities, based upon visual examination, were observed from extracts of celery seed, cumin, fennel seed, basil, oregano, and rosemary belonging to the Apiaceae and Lamiaceae families, respectively. Likewise, the strongest antimicrobial activities were also observed in the Apiaceae and Lamiaceae. No significant antimicrobial and CYP inhibition was observed in the Fabaceae extracts. Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.
ISSN:1482-1826
1482-1826
DOI:10.18433/J3P599