Lithium and cobalt co-doped mesoporous bioactive glass nanoparticles promote osteogenesis and angiogenesis in bone regeneration

• Published in: Frontiers in bioengineering and biotechnology 2024-01, Vol.11, p.1288393-1288393
• Main Authors: Zhang, Xin, Nan, Kai, Zhang, Yuankai, Song, Keke, Geng, Zilong, Shang, Donglong, Fan, Lihong
• Format: Article
• Language: English
• Subjects: angiogenesis; Bioengineering and Biotechnology; bone regeneration; cobalt; lithium; mesoporous bioactive glass nanoparticles; osteogenesis
• ISSN: 2296-4185; 2296-4185
• DOI: 10.3389/fbioe.2023.1288393

Healing of severe fractures and bone defects involves many complex biological processes, including angiogenesis and osteogenesis, presenting significant clinical challenges. Biomaterials used for bone tissue engineering often possess multiple functions to meet these challenges, including proangiogenic, proosteogenic, and antibacterial properties. We fabricated lithium and cobalt co-doped mesoporous bioactive glass nanoparticles (Li-Co-MBGNs) using a modified sol-gel method. Physicochemical analysis revealed that the nanoparticles had high specific surface areas (>600 m /g) and a mesoporous structure suitable for hydroxyapatite (HA) formation and sustained release of therapeutic ions. experiments with Li-Co-MBGNs showed that these promoted angiogenic properties in HUVECs and pro-osteogenesis abilities in BMSCs by releasing Co and Li ions. We observed their antibacterial activity against and , indicating their potential applications in bone tissue engineering. Overall, our findings indicate the feasibility of its application in bone tissue engineering.