The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most importan...

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Published in:Acta biochimica et biophysica Sinica 2023-11, Vol.55 (11), p.1697-1706
Main Authors: Yang, Qianqian, Tian, Hui, Guo, Ziyi, Ma, Zhongliang, Wang, Guangzhi
Format: Article
Language:English
Subjects:
Biomarkers
Carcinogenesis
Carcinoma, Hepatocellular - pathology
Gene Expression Regulation, Neoplastic
hepatocellular carcinoma
HIF-1α
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Liver Neoplasms - pathology
MicroRNAs - genetics
noncoding RNAs
RNA, Long Noncoding - genetics
tumor microenvironment
Tumor Microenvironment - genetics
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Summary:Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1α (HIF-1α) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), comprise a large part of the human transcriptome and play an important role in regulating the tumorigenesis of HCC. This review discusses the role of ncRNAs in hepatocarcinogenesis, epithelial-mesenchymal transition (EMT), and angiogenesis in a hypoxic microenvironment, as well as the interactions between ncRNAs and key components of the TME. It further discusses their use as biomarkers and the potential clinical value of drugs, as well as the challenges faced in the future.
ISSN:1672-9145
1745-7270
DOI:10.3724/abbs.2023231