Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods

The genus comprises numerous untapped medicinal plants that warrant thorough evaluation for their potential as valuable natural sources of herbal medicine or food flavorings. In this study, untargeted metabolomics and in vitro functional methods were employed to analyze fruit extracts from 11 signif...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-02, Vol.29 (5), p.1059
Main Authors: Yong, Xuhong, Wang, Bi, Wang, Mengdi, Lyu, Hui, Yin, Min, Jin, Tong, Feng, Xu, Shan, Yu, Liang, Yan, Wang, Qizhi
Format: Article
Language:English
Subjects:
Alkaloids
Annotations
bioactivities
Chromatography
Euodia
Evodia
Flavonoids
HeLa Cells
Herbal medicine
Humans
Indole Alkaloids
indole quinazoline alkaloids
Mass spectrometry
Metabolism
Metabolites
NMR
Nuclear magnetic resonance
Pharmaceutical industry
Plant Extracts
Plants, Medicinal
Quinazolines
Quinolones
R&D
Research & development
resource exploitation
Rutaceae
Scientific imaging
untargeted metabolomics
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Summary:The genus comprises numerous untapped medicinal plants that warrant thorough evaluation for their potential as valuable natural sources of herbal medicine or food flavorings. In this study, untargeted metabolomics and in vitro functional methods were employed to analyze fruit extracts from 11 significant species of the genus. An investigation of the distribution of metabolites (quinolone and indole quinazoline alkaloids) in these species indicated that ( ) was the most widely distributed species, followed by ( ), ( ), ( ), and ( ). There have been reports on the close correlation between indole quinazoline alkaloids and their anti-tumor activity, especially in fruits which exhibit effectiveness against various types of cancer, such as SGC-7901, Hela, A549, and other cancer cell lines. Additionally, the plant contains indole quinazoline alkaloids, which possess remarkable antibacterial properties. Our results offer novel insights into the utilization of resources in the pharmaceutical industry.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29051059