Myeloperoxidase and its negative relationship with cholesterol efflux capacity in patients with psoriasis: results from an observational cohort study

Dear Editor Inflammation and oxidative stress can lower the functionality of apolipoprotein A-1 (ApoA1) and high-density lipoprotein (HDL) molecules, leading to defective reverse cholesterol transport and accelerating early atherosclerosis [1]. [...]a link between MPO levels and cholesterol efflux i...

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Bibliographic Details
Published in:Journal of translational medicine 2023-10, Vol.21 (1), p.1-743, Article 743
Main Authors: Florida, Elizabeth M., Li, Haiou, Rodante, J., Teague, H. L., Playford, Martin P.
Format: Article
Language:English
Subjects:
Apolipoprotein A
Arteriosclerosis
Atherosclerosis
Cholesterol
Enzymes
High density lipoprotein
Inflammation
Letter to the Editor
Lipoproteins
Low density lipoprotein
Neutrophils
Oxidative stress
Peroxidase
Psoriasis
Regression analysis
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Summary:Dear Editor Inflammation and oxidative stress can lower the functionality of apolipoprotein A-1 (ApoA1) and high-density lipoprotein (HDL) molecules, leading to defective reverse cholesterol transport and accelerating early atherosclerosis [1]. [...]a link between MPO levels and cholesterol efflux in human psoriasis has not been previously investigated. [...]the aim of this study was to evaluate the relationship between MPO concentration and RCT in a cohort of chronically inflamed psoriasis patients. SEE PDF] Similarly, between the two groups, we found no significant difference in HDL or LDL cholesterol, particle number and size, or triglyceride concentration (Table 1).
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-023-04506-8