Clinical significance of prognostic nutritional index (PNI)-monocyte-to-lymphocyte ratio (MLR)-platelet (PLT) score on postoperative outcomes in non-metastatic clear cell renal cell carcinoma

Prognositic nutritional index (PNI), monocyte-to-lymphocyte ratio (MLR) and platelet (PLT) are associated with tumor survival in many human malignancies. Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell...

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Published in:BMC surgery 2023-05, Vol.23 (1), p.117-117, Article 117
Main Authors: Ren, Wenming, Zhang, Hao, Cheng, Li, Zhang, Yu, Yang, Chenglin, Nie, Liang, Yang, Congcong, Yao, Peng, Han, Jie, Zhuo, Dong
Format: Article
Language:English
Subjects:
Anemia
Blood pressure
Carcinoma, Renal Cell - surgery
Clear cell renal cell carcinoma (ccRCC)
Clear cell-type renal cell carcinoma
Clinical outcomes
Clinical Relevance
Clinical significance
Glucose
Hemoglobin
Humans
Hypertension
Kidney cancer
Kidney Neoplasms - surgery
Laboratories
Lymphocytes
Malignancy
Medical prognosis
Metastases
Metastasis
Monocytes
Non-metastatic
Nutrition Assessment
Patients
Platelets
PNI-MLR-PLT score
Postoperative period
Prognosis
Prognostic indicator
Regression analysis
Regression models
Retrospective Studies
Subgroups
Surgery
Survival
Tumors
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Han, Jie
Zhuo, Dong
description Prognositic nutritional index (PNI), monocyte-to-lymphocyte ratio (MLR) and platelet (PLT) are associated with tumor survival in many human malignancies. Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell renal cell carcinoma (ccRCC). In this study, we retrospectively collected the clinicopathological characteristics and prognostic data from 164 cases of non-metastatic ccRCC and aimed to determine the clinical significance of PNI-MLR-PLT score on patients' outcomes after surgery. The optimal cut-off values of PNI (PNI > 47.40 vs PNI  0.31 vs MLR  245 vs PLT 
doi_str_mv 10.1186/s12893-023-02001-x
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Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell renal cell carcinoma (ccRCC). In this study, we retrospectively collected the clinicopathological characteristics and prognostic data from 164 cases of non-metastatic ccRCC and aimed to determine the clinical significance of PNI-MLR-PLT score on patients' outcomes after surgery. The optimal cut-off values of PNI (PNI &gt; 47.40 vs PNI &lt; 47.40), MLR (MLR &gt; 0.31 vs MLR &lt; 0.31) and PLT (PLT &gt; 245 vs PLT &lt; 245) were identified with relative operating characteristic (ROC) curve analysis. The PNI-MLR-PLT score system was established by the value of three indexes, each indication was assigned a score of 0 or 1. Overall survival (OS) and metastasis-free survival (MFS) were analyzed using Kaplan-Meier estimate and Cox regression models. The mean follow-up period was 85.67 months. Eight (5.0%) patients died, 4 (2.0%) relapsed, and 7 (4.0%) developed metastasis after surgery. The 3-year OS and MFS rates were 98.2% and 97.6%, and the 5-year OS and MFS rates were both 90.2%. Our results suggested that PNI-MLR-PLT score negatively correlated with pathological T stage and tumor grade. Survival outcomes revealed that lower PNI-MLR-PLT score is associated with inferior OS (P &lt; 0.001) and MFS (P &lt; 0.001) after surgery. Subgroup analysis regarding pathological T stage, tumor grade and surgical modalities obtained consistent results. univariable and multivariable Cox analysis showed that high PNI-MLR-PLT score was the independent protective factor of tumor survival in non-metastatic ccRCC patients. Our data suggested that PNI-MLR-PLT score could serve as a promising independent prognostic factor in patients with non-metastatic ccRCC.</description><identifier>ISSN: 1471-2482</identifier><identifier>EISSN: 1471-2482</identifier><identifier>DOI: 10.1186/s12893-023-02001-x</identifier><identifier>PMID: 37165423</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Anemia ; Blood pressure ; Carcinoma, Renal Cell - surgery ; Clear cell renal cell carcinoma (ccRCC) ; Clear cell-type renal cell carcinoma ; Clinical outcomes ; Clinical Relevance ; Clinical significance ; Glucose ; Hemoglobin ; Humans ; Hypertension ; Kidney cancer ; Kidney Neoplasms - surgery ; Laboratories ; Lymphocytes ; Malignancy ; Medical prognosis ; Metastases ; Metastasis ; Monocytes ; Non-metastatic ; Nutrition Assessment ; Patients ; Platelets ; PNI-MLR-PLT score ; Postoperative period ; Prognosis ; Prognostic indicator ; Regression analysis ; Regression models ; Retrospective Studies ; Subgroups ; Surgery ; Survival ; Tumors</subject><ispartof>BMC surgery, 2023-05, Vol.23 (1), p.117-117, Article 117</ispartof><rights>2023. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-4dd1b2dc60310566b6495972558e9cd814a9b845030c0a13a1c02944e3db17db3</citedby><cites>FETCH-LOGICAL-c497t-4dd1b2dc60310566b6495972558e9cd814a9b845030c0a13a1c02944e3db17db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2815599489?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37165423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Wenming</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Cheng, Li</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Yang, Chenglin</creatorcontrib><creatorcontrib>Nie, Liang</creatorcontrib><creatorcontrib>Yang, Congcong</creatorcontrib><creatorcontrib>Yao, Peng</creatorcontrib><creatorcontrib>Han, Jie</creatorcontrib><creatorcontrib>Zhuo, Dong</creatorcontrib><title>Clinical significance of prognostic nutritional index (PNI)-monocyte-to-lymphocyte ratio (MLR)-platelet (PLT) score on postoperative outcomes in non-metastatic clear cell renal cell carcinoma</title><title>BMC surgery</title><addtitle>BMC Surg</addtitle><description>Prognositic nutritional index (PNI), monocyte-to-lymphocyte ratio (MLR) and platelet (PLT) are associated with tumor survival in many human malignancies. Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell renal cell carcinoma (ccRCC). In this study, we retrospectively collected the clinicopathological characteristics and prognostic data from 164 cases of non-metastatic ccRCC and aimed to determine the clinical significance of PNI-MLR-PLT score on patients' outcomes after surgery. The optimal cut-off values of PNI (PNI &gt; 47.40 vs PNI &lt; 47.40), MLR (MLR &gt; 0.31 vs MLR &lt; 0.31) and PLT (PLT &gt; 245 vs PLT &lt; 245) were identified with relative operating characteristic (ROC) curve analysis. The PNI-MLR-PLT score system was established by the value of three indexes, each indication was assigned a score of 0 or 1. Overall survival (OS) and metastasis-free survival (MFS) were analyzed using Kaplan-Meier estimate and Cox regression models. The mean follow-up period was 85.67 months. 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Whereas, no study combined PNI-MLR-PLT score and indicated its predictive significance on the prognosis of patients with non-metastatic clear cell renal cell carcinoma (ccRCC). In this study, we retrospectively collected the clinicopathological characteristics and prognostic data from 164 cases of non-metastatic ccRCC and aimed to determine the clinical significance of PNI-MLR-PLT score on patients' outcomes after surgery. The optimal cut-off values of PNI (PNI &gt; 47.40 vs PNI &lt; 47.40), MLR (MLR &gt; 0.31 vs MLR &lt; 0.31) and PLT (PLT &gt; 245 vs PLT &lt; 245) were identified with relative operating characteristic (ROC) curve analysis. The PNI-MLR-PLT score system was established by the value of three indexes, each indication was assigned a score of 0 or 1. Overall survival (OS) and metastasis-free survival (MFS) were analyzed using Kaplan-Meier estimate and Cox regression models. The mean follow-up period was 85.67 months. Eight (5.0%) patients died, 4 (2.0%) relapsed, and 7 (4.0%) developed metastasis after surgery. The 3-year OS and MFS rates were 98.2% and 97.6%, and the 5-year OS and MFS rates were both 90.2%. Our results suggested that PNI-MLR-PLT score negatively correlated with pathological T stage and tumor grade. Survival outcomes revealed that lower PNI-MLR-PLT score is associated with inferior OS (P &lt; 0.001) and MFS (P &lt; 0.001) after surgery. Subgroup analysis regarding pathological T stage, tumor grade and surgical modalities obtained consistent results. univariable and multivariable Cox analysis showed that high PNI-MLR-PLT score was the independent protective factor of tumor survival in non-metastatic ccRCC patients. Our data suggested that PNI-MLR-PLT score could serve as a promising independent prognostic factor in patients with non-metastatic ccRCC.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>37165423</pmid><doi>10.1186/s12893-023-02001-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Anemia
Blood pressure
Carcinoma, Renal Cell - surgery
Clear cell renal cell carcinoma (ccRCC)
Clear cell-type renal cell carcinoma
Clinical outcomes
Clinical Relevance
Clinical significance
Glucose
Hemoglobin
Humans
Hypertension
Kidney cancer
Kidney Neoplasms - surgery
Laboratories
Lymphocytes
Malignancy
Medical prognosis
Metastases
Metastasis
Monocytes
Non-metastatic
Nutrition Assessment
Patients
Platelets
PNI-MLR-PLT score
Postoperative period
Prognosis
Prognostic indicator
Regression analysis
Regression models
Retrospective Studies
Subgroups
Surgery
Survival
Tumors
title Clinical significance of prognostic nutritional index (PNI)-monocyte-to-lymphocyte ratio (MLR)-platelet (PLT) score on postoperative outcomes in non-metastatic clear cell renal cell carcinoma
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