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Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI
This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases. A retrospective study was conducted involving 65 patients with glioblastomas and 27 patients with metastases using a di...
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Published in: | Cancer imaging 2023-08, Vol.23 (1), p.75-13, Article 75 |
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Main Authors: | , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases.
A retrospective study was conducted involving 65 patients with glioblastomas and 27 patients with metastases using a diffusion-weighted imaging sequence with oscillating gradient spin-echo (OGSE, 50 Hz) and a conventional pulsed gradient spin-echo (PGSE, 0 Hz) sequence. In addition to apparent diffusion coefficient (ADC) maps from two sequences (ADC
and ADC
), we generated maps of the ADC change (cADC): ADC
- ADC
and the relative ADC change (rcADC): (ADC
- ADC
)/ ADC
× 100 (%).
The mean and the fifth and 95th percentile values of each parameter in enhancing and peritumoral regions were compared between glioblastomas and metastases. The area under the receiver operating characteristic curve (AUC) values of the best discriminating indices were compared. In enhancing regions, none of the indices of ADC
and ADC
showed significant differences between metastases and glioblastomas. The mean cADC and rcADC values of metastases were significantly higher than those of glioblastomas (0.24 ± 0.12 × 10
mm
/s vs. 0.14 ± 0.03 × 10
mm
/s and 23.3 ± 9.4% vs. 14.0 ± 4.7%; all p |
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ISSN: | 1470-7330 1740-5025 1470-7330 |
DOI: | 10.1186/s40644-023-00595-2 |