Early Measures of TBI Severity Poorly Predict Later Individual Impairment in a Rat Fluid Percussion Model

Background: Multiple measures of injury severity are suggested as common data elements in preclinical traumatic brain injury (TBI) research. The robustness of these measures in characterizing injury severity is unclear. In particular, it is not known how reliably they predict individual outcomes aft...

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Bibliographic Details
Published in:Brain sciences 2023-08, Vol.13 (9), p.1230
Main Authors: Hetzer, Shelby M, Casagrande, Andrew, Qu’d, Dima, Dobrozsi, Nicholas, Bohnert, Judy, Biguma, Victor, Evanson, Nathan K, McGuire, Jennifer L
Format: Article
Language:English
Subjects:
Animal cognition
Brain
Brain research
Cognitive ability
Custom design
early measures
fluid percussion injury
Injuries
Memory
Mental task performance
neurologic severity score
rats
Short term memory
Software
Spontaneous alternation
Traumatic brain injury
traumatic brain injury (TBI)
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Summary:Background: Multiple measures of injury severity are suggested as common data elements in preclinical traumatic brain injury (TBI) research. The robustness of these measures in characterizing injury severity is unclear. In particular, it is not known how reliably they predict individual outcomes after experimental TBI. Methods: We assessed several commonly used measures of initial injury severity for their ability to predict chronic cognitive outcomes in a rat lateral fluid percussion (LFPI) model of TBI. At the time of injury, we assessed reflex righting time, neurologic severity scores, and 24 h weight loss. Sixty days after LFPI, we evaluated working memory using a spontaneous alternation T-maze task. Results: We found that righting time and weight loss had no correlation to chronic T-maze performance, while neurologic severity score correlated weakly. Discussion: Taken together, our results indicate that commonly used early measures of injury severity do not robustly predict longer-term outcomes. This finding parallels the uncertainty in predicting individual outcomes in TBI clinical populations.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13091230