Bacterial and clinical metabolic signatures and their interactions in obese patients post-bariatric surgery

• Published in: BMC gastroenterology 2024-10, Vol.24 (1), p.363-11, Article 363
• Main Authors: Hu, Mengjie, Xiang, Qiaoyuan, Mei, Zixuan, Gong, Cheng, Pan, Dingyu, Liu, Yumin, Li, Zhen
• Format: Article
• Language: English
• Subjects: 16S rRNA analysis; Adult; Bariatric Surgery - methods; Blood Glucose - metabolism; Body Mass Index; Body weight loss; China; Cholesterol; Comorbidity; Correlation analysis; Diabetes mellitus (non-insulin dependent); Diet; Discriminant analysis; Esophagus; Feces; Feces - microbiology; Female; Gastrectomy; Gastrectomy - methods; Gastrointestinal Microbiome; Gastrointestinal surgery; Glucose; Glucose metabolism; Glycated Hemoglobin - metabolism; Gut microbiota; Hemoglobin; High density lipoprotein; Hospitals; Humans; Intestinal microflora; Laparoscopic Sleeve Gastrectomy; Laparoscopy; Lipids - blood; Lipoproteins; Male; Metabolic disorders; Metabolic syndrome; Microbiota; Middle Aged; Obesity; Obesity - metabolism; Obesity - microbiology; Obesity - surgery; Obesity, Morbid - metabolism; Obesity, Morbid - microbiology; Obesity, Morbid - surgery; Overweight; Patients; RNA, Ribosomal, 16S - genetics; rRNA 16S; Software; Surgery; Triglycerides; Weight control; Weight Loss
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-024-03450-1

Obesity is a growing health concern in China, closely linked to metabolic disorders such as type 2 diabetes. Laparoscopic Sleeve Gastrectomy (LSG) is effective in promoting weight loss and improving metabolic outcomes. Emerging evidence highlights the role of gut microbiota in metabolic regulation, yet the specific alterations in gut microbiota and their association with metabolic changes post-surgery in Chinese patients remain unclear. Understanding these shifts could provide key insights into optimizing treatment strategies for metabolic improvement following bariatric surgery. Stool samples and clinical data were collected from 30 obese patients before and 6 months after surgery. The composition of the gut microbiota was analyzed through 16S rRNA sequencing, and Spearman correlation analysis was used to determine the association between gut microbiota and clinical indicators. The analysis of 30 patients showed a significant decrease in Body Mass Index (BMI) (36.75 ± 4.09 kg/m vs 26.37 ± 3.47 kg/m , p