Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain. We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALP...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2020-12, Vol.12, p.559603-559603
Main Authors: Zhou, Wei, Shen, Bo, Shen, Wei-Qiang, Chen, Hao, Zheng, Yi-Feng, Fei, Jing-Jing
Format: Article
Language:English
Subjects:
Age
Aging
Alzheimer's disease
Atrophy
brain
Caudate nucleus
Dentate nucleus
Globus pallidus
glymphatic system
Iron
iron deposition
Magnetic resonance imaging
Metabolism
MRI
Neuroscience
Parkinson's disease
Putamen
Red nucleus
Software
Substantia nigra
Thalamus
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Summary:The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain. We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship. The mean age of participants was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all < 0.001). The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system. We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2020.559603