Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been published on this entity in recent years, a great number of patients and health professionals rem...

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Bibliographic Details
Published in:Diagnostic pathology 2018-01, Vol.13 (1), p.10-10, Article 10
Main Authors: Pastorello, Ricardo Garcia, D'Almeida Costa, Felipe, Osório, Cynthia A B T, Makdissi, Fabiana B A, Bezerra, Stephania Martins, de Brot, Marina, Campos, Antonio Hugo J F M, Soares, Fernando Augusto, Vassallo, José
Format: Article
Language:English
Subjects:
Anaplastic large cell lymphoma
Anaplastic lymphoma kinase (ALK)
Breast cancer
Breast implant
Cancer patients
Case Report
Diagnosis
Epidemiology
Health aspects
Li-FRAUMENI syndrome
Lymphoma
Risk factors
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Summary:Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been published on this entity in recent years, a great number of patients and health professionals remain unaware of this diagnosis. We herein report the case of a 56-year-old female with Li-FRAUMENI syndrome who presented with late right-sided recurrent breast swelling after prophylactic adenomastectomy with implant reconstruction. Imaging scans revealed an heterogeneous mass adjacent to the implant fibrous capsule. A biopsy of the lesion rendered the diagnosis of a BIA-ALCL. This case presents similarities with previous reports, but also some particularities, which should be stressed in order to make the diagnosis the earliest possible. The most distinct feature is that this is the second report of BIA-ALCL arising in the setting of Li-FRAUMENI syndrome.
ISSN:1746-1596
1746-1596
DOI:10.1186/s13000-018-0688-x