Bacillus Amyloliquefaciens-9 as an Alternative Approach to Cure Diarrhea in Saanen Kids

(GBacillus-9), derived from the intestinal tract of the white-spotted bamboo shark, secretes a variety of antimicrobial compounds that inhibit the growth of pathogenic bacteria. In this study, the role of GBacillus-9 in the prevention and treatment of Saanen kids with diarrhea was assessed. Six heal...

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Bibliographic Details
Published in:Animals (Basel) 2021-02, Vol.11 (3), p.592
Main Authors: Zhang, Wenying, Xin, Huijie, Jiang, Nannan, Lv, Zhengbing, Shu, Jianhong, Shi, Hengbo
Format: Article
Language:English
Subjects:
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacillus amyloliquefaciens
Bacteria
Correlation analysis
Cytokines
Dairy farms
Diarrhea
Digestive system
Enteritis
Farm management
Fecal microflora
Feces
Globulins
Homeostasis
Immune system
Immunoglobulins
Infectious diseases
Interleukin 6
intestinal health
Intestine
Metabolism
Metabolites
microbial community
Microbiota
Microorganisms
Milk
Neonates
Pathogens
Prevention
Principal components analysis
Probiotics
Sequence analysis
Sharks
Software
Viruses
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Summary:(GBacillus-9), derived from the intestinal tract of the white-spotted bamboo shark, secretes a variety of antimicrobial compounds that inhibit the growth of pathogenic bacteria. In this study, the role of GBacillus-9 in the prevention and treatment of Saanen kids with diarrhea was assessed. Six healthy kids (HL) and six kids with diarrhea (DL) were selected. All kids were fed with 0.3% (w/v) GBacillus-9 (spray power) in raw milk for two weeks. The proportion of kids with diarrhea decreased gradually as the trial progressed, and 100% DL kids were cured at day 15. GBacillus-9 increased the serum immunoglobulin (Ig) G, interleukin (IL)-4, and IL-6 concentration ( < 0.05). The amplicon sequencing analysis of the fecal bacterial community revealed that the fecal microbiota was remarkably different between the HL and the DL groups at day 0. After two weeks of feeding with GBacillus-9, no significant difference in fecal microbiota was observed between HL and DL groups at the phylum level. GBacillus-9 restored the intestinal microbial disorder associated with serum immunoglobulin and interleukin concentration. Correlation analysis showed that GBacillus-9 altered globulin and interleukin concentration and that immunoglobulin was associated with . Collectively, our results revealed that GBacillus-9 improved the gut health of kids by improving microbial homeostasis.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11030592